OnabotulinumtoxinA (onabotA [Botox]) injections are safe to treat overactive bladder in patients 80 years of age and older, researchers say.
Urinary tract infections are no more common in this population than in younger people, according to Patricia M. Zahner, MD, of Cleveland Clinic. She presented the study at the AUA annual meeting in San Francisco.
"We treat a lot of elderly patients with Botox and it's effective," she told Urology Times.
OnabotA injections are common third-line treatments for overactive bladder. But some providers may be afraid to use them in elderly patients because of the most common adverse events: urinary retention and urinary tract infections.
"We worry that they may get more sick," said Dr. Zahner, who worked on the study with Howard B. Goldman, MD, and colleagues.
To examine the risks of this treatment in older patients, the authors retrospectively reviewed the records of a series of patients who underwent onabotA injections for overactive bladder from 2007 to 2017.
They compared 62 patients with a mean age of 84 years, ranging from 80-94 years, to 68 patients with a mean age of 59 years, ranging from 50-70 years.
There was no significant difference in comorbidities between the two cohorts (65% in the younger cohort and 76% in the elderly cohort, p=.24), or in reported satisfaction (p=.31).
Significantly more of the younger patients (53%) had neurologic conditions than the older patients (29%), p=.006.