San Francisco—Adding abiraterone acetate (ZYTIGA) to androgen deprivation therapy (ADT) for the management of patients with metastatic castration-naïve prostate cancer does not increase medical resource utilization.
Using data from the phase III double-blind placebo-controlled multinational LATITUDE study, researchers led by Tracy Li, PhD, documented significantly lower rates of overnight hospitalization, imaging studies, and radiotherapy for the men randomized to abiraterone compared with placebo. The findings were presented at the Genitourinary Cancers Symposium in San Francisco.
Abiraterone added to ADT in LATITUDE significantly improved overall survival and disease progression compared with placebo and ADT. The economic consequences of adopting abiraterone plus ADT in the 1,199 patients enrolled in LATITUDE were explored by examining event-driven medical resource utilization of study participants. Specifically, medical resources other than those mandated by the study protocol from the first dose of study medication to the last dose were assessed.
“When you have an effective treatment for a disease and you improve the clinical aspects and slow down disease progression, what does that mean to the health care system?” said Dr. Li, director of Global Market Access at Janssen Global Services, Raritan, NJ. “We looked at that question. Improving overall survival and radiographic progression-free survival, slowing down disease progression, and delaying the use of chemotherapy meant a decrease in overnight hospitalization, use of radiotherapy and surgery, and the need for imaging, with trends toward fewer visits to oncologists and urologists.”
The rates of non-protocol-mandated medical resource utilization were 78% for hospitalizations, 81% for imaging, 82% for general practitioner visits, 87% for specialist visits, and 97% for radiotherapy.
The rates of hospitalization in the two arms were 52.71 per 100 person-years in the abiraterone/ADT arm compared with 69.47 per 100 person-years in the placebo/ADT arm, representing a 24% reduction for abiraterone/ADT. The most common reasons for hospitalization were bladder/urethral symptoms (9% frequency), limb fractures/dislocations (6%), spinal cord and nerve root disorders (5%), urinary tract infections (5%), lower respiratory tract and lung infections (4%), febrile disorders (4%), central nervous system hemorrhage and cerebrobascular accident (4%), musculoskeletal/connective tissue pain and discomfort (4%), and bronchospasm and obstruction (4%).