Results ‘durable out to 1 year’
The utilization of AS in GPS-tested men increased, “and that result is durable out to 1 year. At 1 year, men who were tested with GPS were more likely to choose AS and stay on it than men who don’t have the benefit of the test,” Dr. Eure said.
The higher utilization and persistence on AS resulted in a 21% absolute increase (34% vs. 55%) and a 62% relative increase in the proportion of GPS-tested men on AS at 1 year post-diagnosis compared with baseline. The net increase of patients on AS at 1 year was observed across age groups and racial groups.
“We thought we were maxed out on our AS acceptance but using GPS improved that,” said Dr. Eure. “The individual risk refinement provided by genomic testing demonstrates the impact of the GPS in identifying appropriate patients and supporting more AS decisions in clinically low-risk prostate cancer.”
Dr. Eure is a consultant/adviser for Genomic Health, Inc. and has a financial or other relationship with several pharmaceutical companies. Several of his co-authors are employees of and have an investment interest with Genomic Health, and several co-authors have disclosures related to Genomic Health and/or pharmaceutical companies.
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