- An analysis of urinary markers in women with interstitial cystitis/bladder pain syndrome (IC/BPS) showed increased levels of VEGF and CXCL10, presence of the inflammatory cytokine IL-1a, and increased levels of urinary IL-1Ra with hydrodistention or fulguration, suggesting a possible role in alleviation of IC symptoms.
- Analysis of urinary fungal mycobiome in patients with bladder pain and urinary urgency revealed specific fungal community patterns correlated independently with urinary urgency and bladder pain symptoms and that loss of mycobiome diversity correlated positively with symptom severity.
- Genetic linkage analysis of patients with IC/BPS identified variants on chromosome 3 as a potential contributor to IC/BPS predisposition.
- Analysis of mast cell subtypes in patients with IC/BPS showed proliferation and activation of mast cells in a subset of patients with IC, suggesting a potential to develop treatment strategies specific to patients’ mast cell subtype.
- A subgroup of patients with IC/BPS and low anesthetic bladder capacity had a distinct mucosal gene expression profile, suggesting a phenotype potentially amenable to specific treatment strategies.
- A feasibility study of a male chronic genital pain clinic for men with chronic unexplained orchalgia provided rapid access to specialized expertise that led to identification of specific scrotal pathology and effective treatment, which reduced costs of managing the condition.
- Microdenervation of the spermatic cord for post-vasectomy pain syndrome led to successful and durable pain relief in 71% of patients, including those with multiple scrotal structures and those who had not benefited from prior procedures for the pain syndrome.
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