Trial launched for drugs’ use in metastatic, hormone-sensitive PCa
Astellas Pharma Inc. and Medivation, Inc. recently announced the launch of the ARCHES (AR Inhibition with ChemoHormonal Therapy in Men with MEtastatic Castrate Sensitive Prostate Cancer) phase III registrational trial. The study, which will evaluate the efficacy and safety of enzalutamide (XTANDI) with androgen deprivation therapy (ADT) versus placebo with ADT in metastatic hormone-sensitive prostate cancer (mHSPC) patients, has been initiated and the first patient has been randomized. The global, randomized, double-blind, placebo-controlled study, which is being led by Astellas, will enroll approximately 1,100 patients with mHSPC at approximately 250 centers globally. The primary endpoint is radiographic progression-free survival, defined as the time from randomization to the first objective evidence of radiographic disease progression as assessed by central review or death, whichever occurs first.
Agreement reached to investigate efficacy of PCa detection cameras
Aytu BioScience, Inc. has entered into a study agreement with Hybridyne Imaging Technologies to investigate the efficacy of Hybridyne’s ProxiScan compact gamma cameras to detect local prostate cancer using ProstaScint, Aytu’s imaging agent. The study is being conducted at The Princess Margaret Cancer Centre in Toronto, and supported by Hybridyne. As part of the agreement, Hybridyne will purchase ProstaScint for the study.