K.C. Balaji, MD, presents the take home messages on basic science research from the AUA annual meeting in Orlando, FL.
• Copy number loss in NELL1 and a missense mutation linked to inflammation were identified in men with Peyronie’s disease, suggesting a genetic basis for this disease.
• Highly purified collagen coating showed promise for improving the biocompatibility of polypropylene mesh.
• Peripheral fatty acid amide hydrolase is a potential target for treating premature ejaculation.
• Immediate placement of a localized drug delivery system (sildenafil-loaded nanospheres) to the site of nerve injury improved erectile function in rats, suggesting potential application in patients undergoing radical prostatectomy.
• A combination of candidate genes (KISS1R, KISS1, CSAD, and SEPT9) could serve as prognostic markers for risk of primary bladder tumor metastasis.
• Compared to bacillus Calmette-Guérin (TheraCys, TICE BCG)-responsive tumors, high-grade nonmuscle-invasive bladder carcinomas that recur after BCG treatment have increased expression of genes implicated in cancer phenotype, including survival, migration, and invasion.
• Several studies identified miRNA signatures and various biomarkers as possible prognostic markers in renal cell carcinoma.
• Results in a mouse model suggest combination therapy of anti-CTLA4 antibody and anti-PD-1 antibody can be an option in kidney cancer.
• Induction of a hypometabolic state may be a useful strategy to reduce ischemic injury in renal surgery, results from a mouse model suggest.
• Thermotherapy with magnetic cationic liposomes suppressed bone metastasis in a novel rat model when administered with docetaxel (Taxotere).
• Differential expression of miRNAs in biopsies of patients with low-risk prostate cancer may identify patients at risk for upgrading.UT
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