Prostate Cancer

The forum underscored the importance of multidisciplinary collaboration in managing advanced prostate cancer.

As the year comes to a close, we revisit some of this year’s top content on prostate cancer.

The approval is supported by data from the TRITON3 trial.

A key theme throughout the forum was the importance of assessing disease volume and clinical presentation at diagnosis.

When discussing treatment goals, clinicians underscored the importance of individualizing systemic therapy.

The approval is supported by data from the phase 3 AMPLITUDE trial.

"If 2025 showed us anything, it is the power of combining scientific progress with public engagement," writes Michael S. Cookson, MD, MMHC, FACS.

The pilot study plans to enroll patients with locally recurrent prostate cancer across clinical trial sites in the US.

The phase 1 study will assess the safety and feasibility of SPECT/CT imaging with [111In]In-ART-101.

Arvin K. George, MD, discusses the unique design of the VAPOR 2 trial as well as the key findings from the first 110 patients enrolled in the study.

For patients undergoing salvage surgery or radiation, Kelly L. Stratton, MD, FACS, notes that previous focal therapy can influence outcomes.

TULSA patients were treated and discharged the same day.

Stratton emphasized that the trial’s results provide greater confidence in recommending therapy and allow clinicians to counsel patients more decisively about next steps when PSA begins to rise.

Following treatment with SYNC-T, all bone metastases had resolved in 7 of the 13 patients.

The data come just days after the FDA approved IsoPSA to aid in the diagnosis of high-grade prostate cancer.

For micro-ultrasound compared with true cancer status, estimated sensitivity was 0.8000.

The group discussed wide variation in when and how patients transition from urology to medical oncology.

One notable trend is the shift of therapies originally reserved for heavily pretreated, castration-resistant prostate cancer into earlier phases of disease.

The investigators reported that new onset of CNS-related conditions was lower in patients in the apalutamide cohort at 12 months and 24 months post index.

Clinicians noted that symptoms—bone pain, declining function, anemia, and renal compromise—carry significant weight when choosing therapy.

The approval is supported by 12-month data from the prospective VAPOR 2 trial.

A recap of the FDA submissions and regulatory decisions in urology from November 2025.

The test is intended to aid in the decision for prostate biopsy in men aged 50 years or older who present with elevated PSA levels.

Beyond rectal protection, rectal spacers may facilitate curative radiation dosing and reduce the likelihood of local recurrence.

According to the authors, the optimal duration of treatment could be tied to individual patient factors such as cancer risk.