
Opinion|Videos|June 3, 2025
Ultra-Low PSA Response as a Trial End Point or Clinical Decision Point
Author(s)Neal Shore, MD, FACS
Explore the latest advancements in clinical trials for metastatic hormone-sensitive prostate cancer, focusing on innovative treatments and testing methods.
Advertisement
Episodes in this series

Future Applications of Ultra-Low PSA Response
Key Themes:
- Potential use of ultra-low PSA response as a clinical trial end point
- Possibility of using PSA response to guide treatment intensification or de-escalation
- Need for further validation of this approach
Expert Insights:
- Dr Shore discussed the potential for ultra-low PSA response to serve as an end point in future clinical trials.
He highlighted how this metric could potentially influence precision medicine approaches while emphasizing the need for further validation.
Advertisement
Related to this article

Exploratory analyses suggest persistent immune remodeling after aglatimagene plus radiation in localized prostate cancer.

Brian Mazzarella, MD, discusses the landscape for intermediate-risk prostate cancer and early VAPOR 2 findings on water vapor ablation.

The phase 3 BiPASS trial is evaluating the use of 68Ga-PSMA-PET in combination with MRI for pre-biopsy prostate cancer detection.

In RTOG 3506, adding enzalutamide to standard ADT and salvage radiotherapy was associated with 2-year PFS benefit.

In the phase 3 PACE-A trial, SBRT and prostatectomy showed similar 8-year disease control in localized prostate cancer, with lower rates of urinary incontinence after SBRT.

Using PSMA-PET imaging and genomic testing to obtain better information earlier in the disease course changes what clinicians can do with diagnosis and treatment planning.

The registrational study is designed to evaluate the diagnostic performance of 68Ga-DOTA-RM2 vs histopathology in prostate cancer.
Advertisement
Advertisement
Trending on Urology Times
1
AMA issues Category I CPT codes for implantable tibial neuromodulation in UUI
2
The UroOnc Minute: Key Updates to the AUA NMIBC Guideline, With Peter E. Clark, MD
3
Aglatimagene besadenovec shows sustained immune remodeling in localized prostate cancer
4
John Sfakianos, MD, on integrating ctDNA into bladder cancer trials
5
