Opinion|Videos|May 27, 2025
Interpreting PSA Trends in Patients Receiving Darolutamide Plus ADT With mHSPC
Author(s)Neal Shore, MD, FACS
Exploring the impact of ultra-sensitive PSA testing on treatment decisions for metastatic hormone-sensitive prostate cancer, enhancing patient outcomes and care efficiency.
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Episodes in this series
Clinical Implications for PSA Monitoring
Key Themes:
- Real-world implications for urologists monitoring patients on darolutamide plus ADT
- Importance of sensitive PSA assays
- Potential for PSA kinetics to guide treatment decisions
Expert Insights:
- Dr Shore provided guidance on how these findings might influence the way urologists monitor and interpret PSA trends in patients receiving darolutamide plus ADT.
He emphasized the importance of using appropriately sensitive assays and how PSA kinetics could inform treatment intensity or surveillance strategies.
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Alicia Morgans, MD, discusses ARACOG findings on cognitive outcomes with darolutamide vs enzalutamide and the influence of genetic dementia risk.
Aaron Berger, MD, discusses patient selection for ARPI treatment holidays, monitoring during interruptions, and the role of testosterone recovery in interpreting PSA kinetics.
Tamim Niazi, MDCM, reviews DASL-HiCaP findings showing improved metastasis-free survival with darolutamide added to ADT and radiation therapy.
Chad Ritch, MD, discusses differences between PSMA-PET imaging agents and the need for further evidence to guide clinical decision-making.
Chad Ritch, MD, discusses how PSMA-PET informs patient management across different stages of the prostate cancer journey.
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