Complexed PSA may be more specific than total PSA

Orlando FL-Measuring complexed PSA (cPSA) may provide improved specificity over total PSA (tPSA), according to the results of a multicenter trial. In their study, researchers from Innsbruck, Austria; Houston; New York; Cheyenne, WY; Stanford, CA; Baltimore; and Seattle compared the clinical performance of a cPSA test (Bayer Diagnostics, Tarrytown, NY) versus a standard tPSA test and PSA ratios (percent-free PSA and percent cPSA) as a first-line test for detecting prostate cancer.