Dr. Agarwal on HRQoL and PROs with apalutamide in mCSPC
Neeraj Agarwal, MD, a professor of Medicine at the Huntsman Cancer Institute, University of Utah, discusses health-related quality of life (HRQoL) and patient-reported outcomes from the phase 3 TITAN trial of apalutamide (Erleada) in patients with metastatic castration-sensitive prostate cancer (mCSPC).
The TITAN trial (NCT02489318) randomized 1052 patients with mCSPC in a 1:1 ratio to receive apalutamide plus androgen-deprivation therapy (ADT) or placebo plus ADT. The results showed that adding apalutamide to ADT reduced the risk of death by 35% versus ADT alone.
Based on the efficacy and safety data from the primary TITAN analysis, the FDA approved apalutamide for the treatment of patients with mCSPC.
Lenvatinib/pembrolizumab compares favorably with frontline standards in renal cell carcinoma
February 2nd 2024“Combination therapy with lenvatinib plus pembrolizumab provides a comparable OS, and a trend of improvement in PFS and response outcomes, compared with most current global SOC therapies for treatment-naïve patients with advanced renal cell carcinoma,” the study authors wrote.
First-line pembrolizumab/lenvatinib shows efficacy for advanced non–clear cell RCC
January 29th 2024“Updated efficacy and safety results continue to support pembrolizumab plus lenvatinib as a first-line treatment option for patients with advanced non–clear cell RCC,” lead study author Martin H. Voss, MD.
