Arpit Rao, MD, an associate professor of Medical Oncology at Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses the benefit of dual inhibition of the PARP and androgen receptor (AR) pathways in patients with prostate cancer. He also explains that a successful phase 2 trial (doi: 10.1016/S1470-2045(18)30365-6) of the AR pathway inhibitor (ARPI) abiraterone acetate (Zytiga) combined with the PARP inhibitor olaparib (Lynparza) in patients with metastatic castration-resistant prostate cancer (mCRPC) inspired his colleagues and him to launch the CASPAR (Alliance A031902) trial, a randomized phase 3 trial of the ARPI enzalutamide (Xtandi) combined with the PARP inhibitor rucaparib (Rubraca) in patients with mCRPC (NCT04455750).
Study identifies potential biomarkers for response to immunotherapy in urothelial carcinoma
April 12th 2023The investigators identified several genetic factors, including ARID1A mutation, that correlated with survival outcomes in patients with advanced urothelial carcinoma treated with immune checkpoint blockade.
Rapid genetic testing model found feasible for patients with prostate cancer
March 31st 2023"In our sample, nearly 10% of patients [with prostate cancer] had a gene variant that made them eligible for effective new therapies, with faster results than traditional referral for genetic testing and counseling,” said Maria I. Carlo, MD.
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