Arpit Rao, MD, an associate professor of Medical Oncology at Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses the benefit of dual inhibition of the PARP and androgen receptor (AR) pathways in patients with prostate cancer. He also explains that a successful phase 2 trial (doi: 10.1016/S1470-2045(18)30365-6) of the AR pathway inhibitor (ARPI) abiraterone acetate (Zytiga) combined with the PARP inhibitor olaparib (Lynparza) in patients with metastatic castration-resistant prostate cancer (mCRPC) inspired his colleagues and him to launch the CASPAR (Alliance A031902) trial, a randomized phase 3 trial of the ARPI enzalutamide (Xtandi) combined with the PARP inhibitor rucaparib (Rubraca) in patients with mCRPC (NCT04455750).
Grant to fund research on biomarkers for toxicity from prostate cancer radiation
July 11th 2024“By understanding the mirSNP genetic markers that predispose patients to adverse side effects from cancer therapy we can tailor these therapies to minimize harm and maximize efficacy," says Joanne B. Weidhaas, MD, PhD, MS.
Gene-expression signature could serve as biomarker for recurrence in ccRCC
June 26th 2024“Even when we adjusted for other clinical variables, like age or grade of tumor, this signature was still independently associated with recurrence after treatment for this form of kidney cancer," says Simpa S. Salami, MD, MPH.