The immunotherapy/TKI combination significantly improved overall survival versus sunitinib.
Thomas E. Hutson, DO, PharmD, Texas Oncology‐Baylor Charles A. Sammons Cancer Center, discusses findings from the phase 3 CLEAR trial, in which frontline therapy with pembrolizumab (Keytruda) plus lenvatinib (Lenvima) reduced the risk of death by 34% versus sunitinib (Sutent) in patients with advanced renal cell carcinoma (RCC). The combination also improved progression-free survival (PFS) and response compared with sunitinib. In the trial, it was also demonstrated that combining lenvatinib and everolimus improved PFS and objective response rate but not OS versus sunitinib in this setting (J Clin Oncol. 2021; 39[suppl6]:269. doi: 10.1200/JCO.2021.39.6_suppl.269).
KIM-1 emerges as biomarker for MRD, atezolizumab benefit in renal cell carcinoma
June 3rd 2024Circulating kidney injury molecule-1 (KIM-1) may be a biomarker for minimal residual disease, disease recurrence, and benefit from adjuvant atezolizumab in patients with renal cell carcinoma at increased risk of recurrence, according to a retrospective analysis of the phase 3 IMmotion010 trial.