Vinayak G. Wagaskar, MBBS, explains the “obesity paradox”—improved survival outcomes in patients with a high body mass index (BMI)—that has been observed in patients with genitourinary malignancies, including prostate cancer.
Wagaskar also highlights a study presented at the 2021 European Association of Urology Congress which reported evidence of the obesity paradox in patients with metastatic castration-resistant prostate cancer (mCRPC). Specifically, an analysis of nearly 1600 patients with mCRPC enrolled across three phase 3 trials showed that the overall survival rate at 36 months was about 30% in obese patients (BMI >30) compared with 20% in overweight (25< BMI <30) and normal weight (20< BMI <25) patients.
Wagaskar is an instructor of urology at Mount Sinai in New York City.
Phase 1B trial to evaluate relugolix and enzalutamide in high-risk prostate cancer
July 24th 2024"Going forward after this study, we hope to be able to expand and potentially look at patients undergoing either surgery or radiation therapy, and really try to determine the potential benefit," says Kelly L. Stratton, MD, FACS.