Metabolic syndrome and LUTS: An emerging relationship
Increasing evidence has recently pointed toward a relationship between LUTS secondary to BPH and the presence of metabolic syndrome. This relationship has been supported by recent epidemiologic findings.
Epidemiology of metabolic syndrome
LUTS/BPH and metabolic syndrome
A diagnosis of LUTS comprises a spectrum of irritative and obstructive voiding symptoms generally considered a sign of clinically significant BPH. The Third National Health and Nutrition Examination Survey (NHANES III) was a national cross-sectional health survey of 8,814 men and women in the United States conducted between 1988 and 1994 (JAMA 2002; 287:356-9). Subsequently, a subset of 2,372 men 60 years of age or older was evaluated for an association between LUTS and metabolic syndrome. This study found that the presence of LUTS was strongly associated with elevated glycosylated hemoglobin, an accurate predictor of a patient's glucose control over the previous 3 months. A history of diabetes mellitus (Odds Ratio [OR]=1.67) and history of hypertension (OR=1.76) also were found to correlate with the presence of LUTS. An inverse association between high-density lipoprotein levels and the presence of LUTS also was noted.
AUA, SUFU publish 2024 guideline for idiopathic overactive bladder
April 25th 2024“This brand new guideline offers options for all patients with OAB with a focus on shared decision-making between patients with OAB and clinicians, as well as a personalized, tailored approach to care,” said Cameron and Smith.
Enzalutamide granted approval in EU for nmHSPC
April 24th 2024The approval is supported by data from the phase 3 EMBARK trial, which demonstrated that enzalutamide with or without leuprolide prolonged metastasis-free survival compared with leuprolide alone in patients with high-risk biochemically recurrent nmHSPC.
