Metabolic syndrome and LUTS: An emerging relationship
Increasing evidence has recently pointed toward a relationship between LUTS secondary to BPH and the presence of metabolic syndrome. This relationship has been supported by recent epidemiologic findings.
Epidemiology of metabolic syndrome
LUTS/BPH and metabolic syndrome
A diagnosis of LUTS comprises a spectrum of irritative and obstructive voiding symptoms generally considered a sign of clinically significant BPH. The Third National Health and Nutrition Examination Survey (NHANES III) was a national cross-sectional health survey of 8,814 men and women in the United States conducted between 1988 and 1994 (JAMA 2002; 287:356-9). Subsequently, a subset of 2,372 men 60 years of age or older was evaluated for an association between LUTS and metabolic syndrome. This study found that the presence of LUTS was strongly associated with elevated glycosylated hemoglobin, an accurate predictor of a patient's glucose control over the previous 3 months. A history of diabetes mellitus (Odds Ratio [OR]=1.67) and history of hypertension (OR=1.76) also were found to correlate with the presence of LUTS. An inverse association between high-density lipoprotein levels and the presence of LUTS also was noted.
From evidence to practice: Dr. Makarov discusses implementation science in urology
July 25th 2024“What our major contribution is, I think as urologists doing implementation science, is determining the important questions, which we are particularly well-suited to do because we're taking care of the patients,” says Danil V. Makarov, MD, MHS.
Phase 1B trial to evaluate relugolix and enzalutamide in high-risk prostate cancer
July 24th 2024"Going forward after this study, we hope to be able to expand and potentially look at patients undergoing either surgery or radiation therapy, and really try to determine the potential benefit," says Kelly L. Stratton, MD, FACS.
