An overview of new agents and device-assisted therapies being investigated to improve outcomes for patients with superficial bladder cancer.
Bladder cancer is the second most common genitourinary cancer in males and the fourth most common in females. There will be an estimated 71,000 new cases and 14,000 deaths from bladder cancer in 2009.1 Approximately 70% of the time, patients present with superficial disease. Of those, 70% are Ta lesions, 20% T1, and 10% carcinoma in situ (CIS).2
Generally, low-risk tumors are treated with endoscopic resection and immediate post-resection instillation of intravesical chemotherapy. There is strong evidence to support the use of intravesical chemotherapy immediately postoperatively. However, many low-grade superficial tumors that are treated with complete resection alone will never recur. In addition, some believe that it is more cost effective to perform in-office treatment of small, low-grade, visually suspected superficial recurrent lesions than to use postoperative intravesical chemotherapy. However, the use of immediate postoperative intravesical chemotherapy has been shown to decrease recurrence rates by as much as 50% at 2 years and >15% at 5 years.4
An initial complete resection is desirable, as recurrence rates are never as good if any residual tumor remains in the bladder. Mitomycin C (MMC [Mutamycin]) and epirubicin (Ellence) are the two most common agents recommended for immediate post-resection instillation; however, if there is concern that the bladder was perforated during the resection, instillation should be omitted.5
Patients with intermediate- and high-risk tumors require additional intravesical therapy, as these groups carry higher risks of recurrence and progression. When a maintenance regimen is given, bacillus Calmette-Guérin (BCG [TheraCys, TICE BCG]) is the only intravesical agent that has been shown to decrease progression rates.5-7 In the United States, BCG is considered the treatment of choice for high-risk superficial bladder tumors, including CIS, yet some patients either cannot tolerate BCG due to side effects or have BCG-refractory superficial bladder cancer.
AUA, SUFU publish 2024 guideline for idiopathic overactive bladder
April 25th 2024“This brand new guideline offers options for all patients with OAB with a focus on shared decision-making between patients with OAB and clinicians, as well as a personalized, tailored approach to care,” said Cameron and Smith.
Enzalutamide granted approval in EU for nmHSPC
April 24th 2024The approval is supported by data from the phase 3 EMBARK trial, which demonstrated that enzalutamide with or without leuprolide prolonged metastasis-free survival compared with leuprolide alone in patients with high-risk biochemically recurrent nmHSPC.