Pre-treatment antibiotic dip may deter post-penile implant infection
Results of a study comparing the in vitro antibacterial activity of antibiotic-dipped and non-antibiotic-dipped components of inflatable penile implants show differences favoring Titan implants dipped into antibiotic solutions of rifampin-gentamicin or bacitracin-gentamicin compared with the antibiotic (rifampin-minocycline)-coated technology of Inhibizone.
However, it remains to be determined whether these in vitro differences are clinically significant, said lead author Chirpriya B. Dhabuwala, MD, who conducted the study while a professor of urology at Wayne State.
Research from Dr. Dhabuwala's laboratory was the basis for the commercial introduction of antibiotic-coated penile implants. In 1998, Dr. Dhabuwala and colleagues reported results from studies they conducted in a rat model that showed coating silicone strips with rifampin and minocycline significantly reduced infections caused by Staphylococcus epidermidis.
From evidence to practice: Dr. Makarov discusses implementation science in urology
July 25th 2024“What our major contribution is, I think as urologists doing implementation science, is determining the important questions, which we are particularly well-suited to do because we're taking care of the patients,” says Danil V. Makarov, MD, MHS.
