Study of molecularly-guided therapy provides precision medicine insight in mRCC

Article

The results may help guide treatment selection with immunotherapy versus targeted agents in patients with kidney cancer.

A study of molecularly-directed frontline therapy offered insight on the optimal patients to receive various immunotherapy or targeted therapy regimens in the frontline setting for metastatic clear cell renal cell carcinoma (ccRCC).1

The noncomparative, phase 2, biomarker-driven BIONIKK trial randomized 4 groups of patients with distinct tumor microenvironment compositions and prior outcomes with sunitinib (Sutent) to nivolumab (Opdivo) monotherapy, nivolumab plus ipilimumab (Yervoy), or a TKI. The subtypes were identified through previous analysis of transcriptomic data from frozen ccRCC specimens.2,3

Groups 1 (ccrcc1) and 4 (ccrcc4) were “immune-low” and “immune-high,” respectively, and were associated with poor outcomes with sunitinib. Conversely, patients in Groups 2 (ccrcc2) and 3 (ccrcc3) had “angio-high” and “normal-like” tumors, respectively, and were associated with favorable outcomes with sunitinib.

Patients in groups 1 and 4 were randomized to receive alone or nivolumab in combination with ipilimumab. Those in groups 2 and 3 were randomized to receive the combination regimen or physician’s choice of TKI with either sunitinib or pazopanib (Votrient).

The study results, which were presented during the 2020 ESMO Virtual Congress, showed that among all evaluable patients in the target cohort (n = 154), the objective response rate (ORR) was 39.3% with nivolumab monotherapy, 44.5% with nivolumab plus ipilimumab, and 50% with a TKI. The ORRs among evaluable patients in an additional cohort (ACE; n = 33) were 41.7%, 54%, and 25%, respectively.

The ORR with nivolumab alone (n = 29) was 20.7% in group 1. The ORR was 39.4% with nivolumab and ipilimumab (n = 33); 6.1% of these were complete responses (CRs), and 33.3% were partial responses (PRs).

In group 4, the ORR was 50.0% with single-agent nivolumab (n = 14) versus 53.0% with the combination of nivolumab and ipilimumab (n = 17). The CR rates were 7.1% and 11.8%, respectively. The PR rates were 42.9% and 41.2%, respectively.

The ORR was 53.8% with a TKI (n = 26) in group 2, compared with 48.3% with the combination regimen (n = 29). Additionally, 13.8% of patients who received the combination derived CRs.

And among patients in group 3 who received a TKI (n = 2), the ORR was 0% compared with 25.0% with nivolumab/ipilimumab (n = 4). No patients on either regimen derived a CR.

“[The] BIONIKK trial provides evidence on the best candidates to receive TKI, nivolumab alone, or nivolumab/ipilimumab,” said lead study author Yann-Alexandre Vano, MD, PhD, a medical oncologist at Hôpital Européen Georges-Pompidou in Paris, France, during a virtual presentation of the data. “We see the highest response rates with nivolumab alone in patients with ccrcc4 tumors, with durable responses.”

“The poor prognosis of these highly infiltrated tumors seems to be reversed by anti–PD-1 treatment,” added Vano. “In patients with ccrcc1 tumors, combination ipilimumab and nivolumab seems to be needed. In patients with ccrcc2 tumors, TKIs provide very high response rates…at 16 months of follow-up.”

To enroll in the trial, patients had to have metastatic RCC with clear cell histology, though patients with translocation carcinoma were allowed to enroll. Additionally, patients had to be previously untreated in the metastatic setting, have an ECOG performance status of 2 or less, and have frozen tumor tissue available for testing.

A quantitative reverse transcription PCR with a 35-gene signature was performed on frozen tissue samples to classify patients into the 4 molecular groups. Following classification, patients were randomized to their respective treatments.

Between June 2017 and July 2019, 15 centers in France screened 308 patients for potential enrollment on the study. In total, 106 patients were excluded from the trial due to not meeting inclusion criteria (n = 43), not having available frozen tissue and/or insufficient quality of specimen (n = 57), declining to participate (n = 4), or patient death during screening (n = 2).

In the target cohort, baseline characteristics were similar between all randomized patients. Common sites of metastases included the lung, lymph node, bone, liver and brain. Additionally, the majority of patients (>50%) had intermediate or poor–risk disease by International Metastatic RCC Database criteria.

At a median follow-up of 16 months, the median progression-free survival (PFS) in Group 1 was 8.0 months with the combination of nivolumab and ipilimumab versus 4.6 months with nivolumab alone. In Group 4, the median PFS was 12.2 months versus 7.8 months, respectively.

The median PFS in group 2 was not reached in the TKI arm compared with 10.4 months with nivolumab plus ipilimumab. In Group 3, the Kaplan-Meier curve was not shown due to the limited number of patients enrolled in the cohort.

At the median follow-up time, 16% of overall survival (OS) events were observed, which translated to immature OS findings.

No statistical tests were performed due to the noncomparative design of the BIONIKK trial.

The median duration of response (DOR) in Group 1 was 6.7 months with nivolumab alone versus 13.9 months with the combination. The median time to response (TTR) was 2.5 months and 2.2 months, respectively. Comparatively, the median DOR in Group 4 was 15.0 months with nivolumab versus 12.3 months with the combination. The median TTR was 2.2 months and 3.5 months, respectively.

The DOR with the combination was 12.0 months in Group 2 versus 20.2 months in Group 3. With a TKI, the DOR was 8.4 months in Group 2; the DOR was not evaluable (NE) in Group 3. The median TTR with the combination was 2.3 months in Group 2 versus 2.2 months in Group 3. With a TKI, the median TTR was 3.1 months and NE, respectively.

“The main findings are that the vast majority of patients responded at the first CT scan,” said Vano, referencing a swimmer plot that was presented with the data. “This is particularly the case for [treatment with] nivolumab [alone] in group 4. In Group 2, around 30% of patients responded very late—after 10 months—which is very uncommon with TKIs.”

Though early, a transcriptomic analysis of immune cells distribution showed that tumors in Group 4 have the highest level of infiltration by immune cells, particularly cytotoxic lymphocytes.

“A huge biomarker program including transcriptomic analyses, in situ protein expression, and analyses of circulating immune cells is currently ongoing,” concluded Vano.

References

1. Vano Y, Elaidi R, Bennamoun M, et al. Results from the phase 2 BIOmarker driven trial with nivolumab (N) and ipilimumab or VEGFR tyrosine kinase inhibitor (TKI) in naïve metastatic kidney cancer (m-ccRCC) patients (pts): the BIONIKK trial (NCT02960906). Presented at: 2020 ESMO Congress; September 19-21, 2020; Virtual. Abstract: LBA25.

2. Beuselinck B, Job S, Becht E, et al. Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting. Clin Can Research. 2015;21(6):1329-1339. doi:10.1158/1078-0432.CCR-14-1128

3. Becht E, Giraldo NA, Beuselinck B, et al. Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC). OncoImmunology. 2015;4(12):e1049804. doi:10.1080/2162402X.2015.1049804

Related Videos
Nazih Paul Khater, MD, FACS, answers a question during a Zoom video interview
Dr. Mayer Fishman in an interview with Urology Times
Dr. Laurence Albiges in an interview with Urology Times
Dr. Jasmeet Kaur in an interview with Urology Times
Dr. Martin Voss in an interview with Urology Times
Dr. Jacqueline Brown in an interview with Urology Times
blurred clinic hallway
Dr. Dalia Kaakour in an interview with red Urology Times backdrop
Dr. Maria Teresa Bourlon in an interview with Urology Times
Dr. David Braun in an interview with Urology Times
Related Content
© 2024 MJH Life Sciences

All rights reserved.