Here is some of the top content on genomic testing from the past year.
There’s been an abundance of news surrounding genomic testing over the past year. In light of all the progress that’s been made, Urology Times® is recapping the top pieces of content on genomic testing from the past 12 months.
Veda N. Giri, MD, offered a preview of the ENGAGEMENT Study Virtual Genetics Board’s case discussion, which took place on January 18, 2022, and focused on data on TP53 mutations and prostate cancer risk as well as TP53-related management. Watch now.
Daniel E. Spratt, MD, discussed the takeaways of the study, “Validation of the performance of the Decipher biopsy genomic classifier in intermediate-risk prostate cancer on the phase III randomized trial NRG Oncology/RTOG 0126,” which was presented at the 2022 ASCO Genitourinary Cancers Symposium. Watch now.
Sameer Thakker, MD, discussed noteworthy findings from the Urology Practice study, “Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate and Breast/Ovarian Cancer,” for which he served as a study author. Watch now.
Neal D. Shore, MD, FACS, discusses the takeaways of the study, “Hereditary cancer risk assessment in the community urology practice setting,” which was presented at the 2022 ASCO Genitourinary Cancers Symposium. Watch now.
Individuals who are referred for genetic testing for hereditary cancer or other medical conditions may have concerns about the risks of testing, especially if a mutation is discovered, and how this information might be used by others. Read more.
“We really try to be careful about testing, especially when it's a potential burden of costs on the patient. What we really look at is where it's going to have an impact,” said Stephen J. Savage, MD. Watch now.
Findings from the BIONIKK study published in The Lancet Oncology suggest that biomarker-driven treatment selection based on tumor molecular phenotype may be on the horizon in the treatment paradigm for metastatic renal cell carcinoma. Read more.
In a presentation at the 15th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies, Leonard G. Gomella, MD, explained how the ever-expanding application of genetic and genomic testing has launched the game-changing precision medicine era in prostate cancer. Read more.
Pedro C. Barata, MD, MSc, discussed the importance of tumor sequencing to the implementation of precision medicine for patients with urothelial carcinoma. Watch now.
The Centers for Medicare and Medicaid Services covered the Signatera molecular residual disease test for use in patients with muscle-invasive bladder cancer, according to Natera, the developer of the assay. Read more.
Prostate cancer genomic tests show prognostic value for progression, therapy benefit
April 22nd 2024"This preplanned ENACT trial biomarker analysis demonstrates the value of the Decipher score, AR-A score, and PAM50 genomic classifiers in identifying patients undergoing AS who are most likely to benefit from enzalutamide treatment," wrote the authors.
Personalized therapeutic approaches in ccRCC remain challenging
April 15th 2024"As a kidney cancer community, we need to investigate these molecular subtypes prospectively in clinical trials to determine whether specific subtypes benefit from certain therapies or not," says David A. Braun, MD, PhD.
Dr. Xu on why biomarkers are needed for individualized treatment approaches in RCC
April 5th 2024“Systemic therapy for RCC has changed very quickly. Every year, it's exciting to see that we're getting new developments, new drug approvals, and changes in the standard of care,” says Wenxin (Vincent) Xu, MD.