Treat infertile males beyond their reproductive concerns
One does not have to go far on the Internet to find solicitations encouragingcouples whose infertility derives from a wide variety of causes to undergointracytoplasmic sperm injection with aspirated testicular sperm. Many ofthese advertisements hint that ICSI with aspirated sperm is an easy, "one-stop"method of conceiving a child, leading urologists to be rightly concernedthat, without adequate evaluation of the male half of the equation, thepatient's medical interests are inadequately served.
Engy Habashy, MD, discusses key takeaways from the 2025 AUA GSM guideline, including the role of androgens and hormonal therapies in managing genitourinary syndrome of menopause.
The phase 1/2 CELC-G-201 study found preliminary antitumor activity and manageable toxicity with gedatolisib plus darolutamide in metastatic castration-resistant prostate cancer.
Kim Chi, MD, FRCPC, discusses the rationale and design of the phase 3 KLK2-comPAS trial evaluating pasritamig alone and in combination with JNJ-9401 in patients with mCRPC.
Chad R. Ritch, MD, MBA, FACS, discusses how PSMA-PET informs staging, treatment planning, recurrence workup, and the interpretation of equivocal findings.
Michael S. Cookson, MD, MMHC, FACS, discusses how Anktiva’s expanded FDA approval may broaden bladder-preserving treatment options for BCG-unresponsive papillary-only NMIBC.