The Evolving Treatment Landscape of Low-grade Upper Tract Urothelial Carcinoma

This digital series explores challenges and unmet needs in the treatment of low-grade upper tract urothelial carcinoma (LG-UTUC) and reviews key advancements in the therapeutic landscape with emphasis on emerging precision medicine-based approaches.

EP. 1A: Key Considerations in the Diagnosis and Treatment of Upper Tract Urothelial Carcinoma

June 22nd 2022

In the first video of the series, Jennifer A. Linehan, MD, provides an overview of LG-UTUC including risk factors, signs and symptoms, and diagnosis as well as factors to consider regarding disease progression, recurrence, and which patients might be candidates for resection.

EP. 1B: Low-grade Upper Tract Urothelial Carcinoma: Disease Overview

June 30th 2022

In this companion article, Jennifer A. Linehan, MD, from the John Wayne Cancer Institute in Santa Monica, California, shares expert insight into factors affecting LG-UTUC diagnosis and treatment.

EP. 2A: The Role of Kidney-sparing Treatment Approaches for Low-grade UTUC

July 13th 2022

In the second video interview of the series, Sandip M. Prasad, MD, MPhil, reflects on the role of radical nephroureterectomy and endoscopic resection in patients with high- or low-grade UTUC and highlights clinical experience with kidney-sparing approaches including the use of mitomycin gel.

EP. 2B: Radical Nephroureterectomy vs Kidney-sparing Approaches for Patients with LG UTUC

July 27th 2022

In this companion article, Sandip M. Prasad, MD, MPhil, from the Morristown Medical Center in New Jersey discusses the historic use of radical nephroureterectomy and provides an overview of his clinical experience using kidney-sparing approaches for LG UTUC.

EP. 3A: Mitomycin Gel for the Treatment of Low-grade Upper Tract Urothelial Carcinoma

August 3rd 2022

In the third interview of the series, Sam S. Chang, MD, MBA, from the Vanderbilt University Medical Center shares key insights into the role of mitomycin gel as a kidney-sparing approach to the treatment of low-grade upper tract urothelial carcinoma.

EP. 3B: Mitomycin-containing Reverse Thermal Gel Technology as a Kidney-sparing Treatment Option for Patients with LG UTUC

August 11th 2022

In this companion article, Sam S. Chang, MD, MBA, offers his expert perspective on the use of mitomycin gel as a kidney-sparing approach to the management of low-grade upper tract urothelial carcinoma.

EP. 4A: The Importance of Patient Education When Selecting Treatments for Low-grade UTUC

August 24th 2022

In the fourth interview of the series, Armine K. Smith, MD, from Sibley Memorial Hospital in Washington DC highlights considerations when discussing LG UTUC treatment options with patients including key points about response rates, adverse effects and long-term consequences, treatment availability, and insurance challenges.

EP. 4B: Educating Patients on Their Treatment Options for LG UTUC

August 31st 2022

In this companion article, Armine K. Smith, MD, reflects on the role of kidney-sparing approaches for LG UTUC and emphasizes the importance of patient-provider communication when making treatment decisions.