2026 AUA/SUO Advanced Prostate Cancer Guideline: Key updates and clinical FAQs

The American Urological Association (AUA) and the Society of Urologic Oncology (SUO) have released the 2026 amendment to the Advanced Prostate Cancer Guideline, incorporating evidence published from early 2022 through mid-to-late 2025.¹ The update reflects substantial shifts across the disease continuum—from biochemical recurrence after exhaustion of local therapy through metastatic castration-resistant prostate cancer (mCRPC)—with significant new recommendations on treatment intensification, imaging, genetic testing, and bone health. As Kristen R. Scarpato, MD, MPH, who served on the amendment panel, noted, "Even though that's not a huge time period, so much has changed. There was a lot of new information that we incorporated into the guideline."