Perioperative durvalumab (Imfinzi) plus neoadjuvant enfortumab vedotin-ejfv (Padcev) cut the risk of EFS events by 49% and death by 42% in cisplatin-ineligible MIBC.
|Articles|April 28, 2003
BCG failure leads to heightened risk of bladder cancer death
Chicago-Patients with carcinoma in situ or recurrent Ta, Tis, or T1 bladdercancer are at increased risk of dying of the disease within 5 years unlessthey achieve a complete response with bacille Calmette-Guérin therapy,say researchers from the Southwest Oncology Group.
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The PROTEUS substudy addresses a key limitation of the main study, which had no surgery-alone control arm.
At a median follow-up of 60.9 months, median EFS was 74.1 months in the pembrolizumab arm and not reached in the placebo arm.
The phase 1/2 CELC-G-201 study found preliminary antitumor activity and manageable toxicity with gedatolisib plus darolutamide in metastatic castration-resistant prostate cancer.
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