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Dr. Kamran on the state of bladder preservation in 2023


“We've made great strides with bladder preservation on many fronts,” says Sophia C. Kamran, MD.

In this video, Sophia C. Kamran, MD, discusses the current state of bladder-sparing treatment in muscle-invasive bladder cancer. Kamran is a radiation oncologist at the Massachusetts General Hospital Cancer Center and Assistant Professor of Radiation Oncology at Harvard Medical School, Boston, Massachusetts.


Where are we with bladder preservation in 2023?

We have come a long way. We've made great strides with bladder preservation on many fronts, but I would say, in particular, that radiotherapy has come a long way. There have been many great advances in imaging and targeting technology. For patients, that's a huge win. We see lower toxicity rates; we see better tolerance of the regimen overall. And I think it's becoming more widely adopted in the United States. We see more centers that are offering bladder preservation. A few years ago, [we saw] the opening of the largest bladder preservation trial that's currently ongoing, the NRG/SWOG 1806 trial. This is evaluating bladder preservation with standard chemo radiotherapy vs chemo radiotherapy plus adding an immunotherapy agent, atezolizumab [Tecentriq]. It is accruing very well, it's very large, and there are many centers that have it open. So I think we have come a long way in the past decade or so. I'm excited for all the future opportunities to improve upon bladder preservation for our patients.

This transcript has been edited for clarity.

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