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The presentations of Jay Pearson, PhD, and Brett Carver, MD, cited in this issue of Urology Times, provide further experimental and epidemiologic evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) may have some role in the fight against prostate cancer. While these are certainly not the first reports that NSAIDs might beuseful for the prevention or treatment of this malignancy, they continueto identify the remarkable value of these agents for human health and raiseimportant questions as to why so many different types of disease statesare affected by them. Arthritis, benign cardiac conditions, and colon andprostate cancer are diseases of extraordinarily different tissues, etiologies,pathologies, and outcomes. Yet each of these conditions are likely benefitedby NSAID therapy.