Herbal extract may suppress PCa cell growth

December 1, 2005

An herbal extract preparation known as Zyflamend appears to suppress the growth of prostate cancer cells and induces the cells to self-destruct, according to Columbia University researchers.

An herbal extract preparation known as Zyflamend appears to suppress the growth of prostate cancer cells and induces the cells to self-destruct, according to Columbia University researchers. Their study showed that the formulation has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78% and appeared to confirm that it has COX-1 and COX-2 anti-inflammatory effects.

“Zyflamend is derived from natural herbal sources and is readily available in health food and nutritional supplement stores,” said lead author Debra L Bemis, MD. “Given the impressive data we’re reporting, Zyflamend is a potentially more convenient and desirable means to target the enormous population that is susceptible to prostate cancer.”

The agent’s anti-cancer effects were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation. Zyflamend’s biochemical action profile resembles aspirin more than selective COX-2 inhibitors, Dr. Bemis said.

On the strength of this laboratory research, the investigators have commenced a phase I human clinical trial testing the therapy’s ability to prevent prostate cancer in patients with prostatic intraepithelial neoplasia.

Study results were published in Nutrition and Cancer (2005; 52:202-12).