How to treat refractory OAB using injectable botulinum toxin

May 1, 2005

No patient has developed urinary retention or elevated post-void residuals following our modified injection technique.

All patients receive perioperative oral antibiotics and are followed by phone or office interview. In addition, patients undergo post-void residual measurement with bladder ultrasound during clinic visits.

Up to this point, 10 patients with refractory idiopathic overactive bladder have been treated utilizing our novel injection technique. Subjective improvement rates are similar to our previously reported rates (ie, 80%) in OAB patients using 30 to 40 sites of injection.

Beneficial effects of the treatment are noted 7 to 10 days after injection, with durable responses lasting between 3 months and 6 months.