Jared S. Winoker, MD, discusses real-world study of CVAC 2.0 for kidney stones

Findings of a study presented at the American Urological Association 2025 Annual Meeting in Las Vegas, Nevada indicated that treatment of kidney stones with the CVAC 2.0 system is safe and efficacious for a wide range of stone burdens.¹

In an interview with Urology Times®, study author Jared S. Winoker, MD, discussed the real-world nature of the study.

“The study reflects the practices of 21 different surgeons, all with varying experience treating stones and with the device, as well as varying subspecialty expertise. In fact, most of them were not endourologists. I really think that this great degree of heterogeneity and experience performing CVAC itself really helps contribute to that real-world practice. In reality, some of the surgeons only performed 2 or 3 cases, contributing to the data. And I think that that, along with the differences we see in how post op follow-ups were performed on a per surgeon basis, although that may have influenced some of the reported effectiveness, with regards to stone-free rates, we still observed an exceedingly high degree of safety across the board, with very few complications,” said Winoker, director of endourology and director of the Center for Kidney Stone Disease at Lenox Hill and an assistant professor of urology at The Zucker School of Medicine at Hofstra/Northwell in New York, New York.

Asked for the take-home message of the study, Winoker said, “We've clearly demonstrated here that in a very large cohort of patients and urologists that the CVAC system and its associated procedure is very safe and will be an important new player in the kidney stone treatment paradigm. We see that it's highly effective, even with considerably larger stone burdens that would otherwise result in inferior stone clearance ureteroscopically. But at the same time, I think it's important to respect the adoption of CVAC in your practice as you would any new treatment modality regarding patient selection and relying on available resources for learning and optimizing this technique.”

REFERENCE

1. Klyde DM, Aro T, Okeke Z, Hoenig DM, Rai A, Winoker JS. Real-world experience with CVAC 2.0 for steerable ureteroscopic renal evacuation in a large, multi-site academic institution. J Urol. 2025;213(5S2). e36. doi:10.1097/01.JU.0001109712.09934.41.06