Feature|Articles|March 18, 2026

Laurence Klotz, MD, FRCSC, reveals the impact of micro-ultrasound on his prostate cancer practice

Fact checked by: Patrick Campbell

The OPTIMUM randomized trial demonstrated that microultrasonography-guided biopsy is noninferior to MRI fusion-guided biopsy for detecting clinically significant prostate cancer, with a streamlined in-office workflow, a manageable learning curve, and substantially lower cost that may help address diagnostic access gaps worldwide.

Results from the OPTIMUM trial (NCT05220501) have established that microultrasonography-guided biopsy is noninferior to MRI/conventional ultrasonography fusion-guided biopsy for detecting clinically significant prostate cancer in biopsy-naïve men, offering a faster, more accessible in-office alternative to the current standard of care.