Lorraine Scanlon, MD, on relief of venous congestion in RCC with IVC tumor thrombus

In an interview at the 2025 Society of Urology Oncology Annual Meeting in Phoenix, Arizona Lorraine Scanlon, MD, sat down with Urology Times® to discuss her late-breaking abstract, “Relief of Venous Congestion as a Modifiable Cause of Renal Dysfunction in RCC with IVC Tumor Thrombus: A Comparative Cohort Study.” Scanlon is an SUO fellow at London Health Sciences Center in London, Ontario, Canada.

The study assessed 3 cohorts of patients: those who had radical nephrectomy plus thrombectomy, those who had radical nephrectomy alone, and those who had laparoscopic nephrectomy alone. Overall, patients in the IVC thrombectomy group demonstrated improved long-term renal preservation post-operatively compared with the non-thrombus cohorts.

“Despite having worse baseline EGFR, larger tumors, [and] higher ASA grades, the IVC thrombus group actually had better preserved renal function, and their absolute and percentage decline in EGFR was significantly smaller than patients who just had a radical nephrectomy or a laparoscopic nephrectomy,” Scanlon explained. “This suggested to us that there was a reversible pattern, and this was due to their relief of the venous outflow tract obstruction caused by the traumas.”

REFERENCE

1. Scanlon L. Late Breaking Abstract: Relief of Venous Congestion as a Modifiable Cause of Renal Dysfunction in RCC with IVC Tumor Thrombus: A Comparative Cohort Study. Presented at: Society of Urologic Oncology Annual Meeting; December 2-5, 2025; Phoenix, Arizona