Wyeth Pharmaceuticals has announced initiation of the INTORACT (INvestigation of Torisel and Avastin Combination Therapy) study, a randomized, open-label phase III study comparing temsirolimus (Torisel) plus bevacizumab (Avastin) versus bevacizumab plus interferon-alfa for first-line treatment of patients with advanced renal cell carcinoma.
Wyeth Pharmaceuticals has announced initiation of the INTORACT (INvestigation of Torisel and Avastin Combination Therapy) study, a randomized, open-label phase III study comparing temsirolimus (Torisel) plus bevacizumab (Avastin) versus bevacizumab plus interferon-alfa for first-line treatment of patients with advanced renal cell carcinoma.
The primary endpoint of the study is independently assessed progression-free survival of patients in all risk groups. Secondary endpoints include safety, investigator-assessed progression-free survival, independently assessed objective response rate, and overall survival.
A treatment regimen combining temsirolimus with bevacizumab was shown in a phase I-II trial of patients with stage IV renal cancer to have an acceptable safety profile and supported further investigation in a phase III study.
“We hope to learn whether a regimen that combines the angiogenesis inhibition of bevacizumab with the mTOR inhibition of temsirolimus may provide further evidence of clinical utility in advanced RCC,” said Brian Rini, MD, co-principal investigator of INTORACT at Cleveland Clinic.
AUA, SUFU publish 2024 guideline for idiopathic overactive bladder
April 25th 2024“This brand new guideline offers options for all patients with OAB with a focus on shared decision-making between patients with OAB and clinicians, as well as a personalized, tailored approach to care,” said Cameron and Smith.
Enzalutamide granted approval in EU for nmHSPC
April 24th 2024The approval is supported by data from the phase 3 EMBARK trial, which demonstrated that enzalutamide with or without leuprolide prolonged metastasis-free survival compared with leuprolide alone in patients with high-risk biochemically recurrent nmHSPC.