• Benign Prostatic Hyperplasia
  • Hormone Therapy
  • Genomic Testing
  • Next-Generation Imaging
  • UTUC
  • OAB and Incontinence
  • Genitourinary Cancers
  • Kidney Cancer
  • Men's Health
  • Pediatrics
  • Female Urology
  • Sexual Dysfunction
  • Kidney Stones
  • Urologic Surgery
  • Bladder Cancer
  • Benign Conditions
  • Prostate Cancer

Research points to expanding role of botulinum toxin in several urologic indications


In this interview, Michael B. Chancellor, MD, discusses using botulinum toxin for treating overactive bladder, BPH, interstitial cystitis, and other conditions.

The process by which this biological neuromodulator works is incredibly elegant. It has one of the highest affinities of any chemical or biologic ever discovered, meaning that even the smallest amount presented to a nerve terminal will irreversibly bind to the presynaptic neuronal membrane, enter the cell, and block specific Soluble NSF Attachment Protein Receptor (SNARE) proteins that would normally allow the release of the neurotransmitter that's essential for all muscle and sensory neuropeptide release.

Q: Let's talk about the use of botulinum toxin in overactive bladder. Is it important to distinguish between neurogenic and idiopathic overactivity for the purposes of this discussion?

Q: How does botulinum toxin work in OAB? Do we know whether nerve growth factor produced in the urothelium is actually excreted in the urine?

NGF implies neuroinflammation and abnormal nerve function. If the NGF level changes, you know the treatment is having a significant effect. The correlation between responders and non-responders is very exciting.

Related Videos
Gary D. Steinberg, MD, an expert on bladder cancer
Akhil Das, MD, FACS, answers a question during a video interview
Edward M. Schaeffer, MD, PhD, answers a question during a Zoom video interview
Woman talking with doctor | Image Credit: © rocketclips - stock.adobe.com
Blur image of hospital corridor | Image Credit: © whyframeshot - stock.adobe.com
Gamal M. Ghoniem, MD, FACS, ABU/FPMRS, gives an answer during a video interview
Related Content
© 2024 MJH Life Sciences

All rights reserved.