• Benign Prostatic Hyperplasia
  • Hormone Therapy
  • Genomic Testing
  • Next-Generation Imaging
  • UTUC
  • OAB and Incontinence
  • Genitourinary Cancers
  • Kidney Cancer
  • Men's Health
  • Pediatrics
  • Female Urology
  • Sexual Dysfunction
  • Kidney Stones
  • Urologic Surgery
  • Bladder Cancer
  • Benign Conditions
  • Prostate Cancer

Role of BMD studies, bisphosphonates in men on ADT


This article reviews the current state of knowledge of the incidence and pathophysiology of bone loss and skeletal events in patients with prostate cancer who are on ADT.

Key Points

Effect of ADT on bone loss

In fact, it is thought that the incidence of osteopenia and osteoporosis in men treated with ADT exceeds that observed in postmenopausal women (Urology 2002; 60:79-85). Further, even before ADT or the occurrence of bone metastases, patients with prostate cancer already have reduced BMD compared to healthy controls. The presence of other risk factors, such as hypogonadism, decreased vitamin D and calcium intake, and heredity could explain this observation.

Such considerations imply that prophylactic and therapeutic measures similar to those being practiced in postmenopausal women could be applicable in men with prostate cancer, whether they are on or off ADT.

Related Videos
Blurred interior of hospital |  Image Credit: © jakkapan - stock.adobe.com
Laura Bukavina, MD, MPH, answers a question during a Zoom video interview
Image of kidneys | Image Credit: © peterschreiber.media - stock.adobe.com
Neal Shore, MD, FACS, and Brian M. Shuch, MD, experts on kidney cancer
Neal Shore, MD, FACS, and Brian M. Shuch, MD, experts on kidney cancer
Blur image of hospital corridor | Image Credit: © whyframeshot - stock.adobe.com
Related Content
© 2024 MJH Life Sciences

All rights reserved.