Brittany Lovely

Findings from cohort 1 of the phase 2 LITESPARK-003 trial showed that the combination of belzutifan (Welireg) and cabozantinib (Cabometyx) had promising clinical activity as a first-line treatment for patients with advanced clear cell renal cell carcinoma (RCC).

The results, which were presented at the 2022 ESMO Congress, showed that at a median follow-up of 14.0 months, the objective response rate (ORR) per investigator assessment was 57% among 35 treated patients. The complete response (CR) and partial response (PR) rates were 6% and 51%, respectively, with stable disease (SD) reported in 13 patients (37%). Combined, this resulted in a disease control rate (DCR) of 94%. No patients experienced disease progression. Two patients did not have an opportunity for assessment postbaseline but were reported as remaining on treatment at data cutoff.

“Responses occurred across all International mRCC Database Consortium risk groups—both in the favorable and intermediate/poor risk groups,” Jamie R. Merchan, MD, said in a presentation of the data. “The data have led us to preliminarily conclude that dual targeting of HIF-2α and VEGF pathways may be an effective treatment strategy in advanced clear cell RCC.” Merchan is medical oncologist with the University of Miami Health System.

In the favorable-risk group (n = 21), the ORR was 62%, with 2 patients (10%) having a CR and 11 patients (52%) having a PR to treatment. Stable disease was reported in 29% of patients for a DCR of 90%. In the intermediate/poor-risk group (n = 14), the ORR was 50% with patients either having a PR (50%) or SD (50%), translating to a DCR of 100%.

The median time to response was 1.9 months (range, 1.7-9.2) and the median duration of response was 28.6 months (range, 1.7+ to 28.6), with 78% of responders having a response of at least 12 months. At the time of data cutoff, 25 patients (71%) remained on treatment.

Belzutifan, a potent and selective HIF-2α inhibitor, was initially evaluated in heavily pretreated patients in early-phase studies and demonstrated encouraging response and DCR rates across risk groups, according to Andre Fay, MD, an invited discussant of the abstract. He pointed to data from the phase 1/2 trial (NCT02974738), which showed that single-agent belzutifan elicited an ORR of 24% with a DCR of 24% among 55 treated patients.

“Anti-VEGF increases HIF-2α concentration, providing a rationale for the combination of the [2] inhibitors,” said Fay, who is a professor of medicine PUCRS School of Medicine and chief of the Medical Oncology Department at the Hospital Sírio-Libanês in Brazil.

LITESPARK-003 enrolled patients with locally advanced or metastatic clear cell RCC who were either treatment-naïve (cohort 1) or had received treatment with no more than 2 prior lines of immunotherapy for advanced or metastatic RCC (cohort 2). Patients must have had an ECOG performance status of 0 or 1.1

In cohort 1, patients received belzutifan at 120 mg plus cabozantinib at 60 mg, both administered orally once daily.

The median age of the patients was 64.0 years (range, 33-89) and most were men (83%). The majority had an ECOG performance status of 0 (60%) and favorable-risk disease (60%). Twenty-six patients (74%) received prior nephrectomy.

In an analysis of best percentage change from baseline in tumor lesions, Merchan noted that 1 patient with a CR had an 88% reduction in both nodal and non-nodal lesions, with the non-nodal lesion having 100% reduction in size and the lymph node being reduced to fewer than 10 mm in diameter.

Progression-free survival (PFS) and overall survival (OS) estimates were also presented. The median PFS was 30.3 months (95% CI, 9.4–not reached [NR]), with 67% of patients free of progression at 12 months. At the time of data cutoff, 2 patients died, and the median OS was not reached. The 12-month OS rate was 96%.

Treatment-related adverse effects (TRAEs) were reported in 97% of patients. Grade 3 or higher TRAEs occurred in 37% of patients with no grade 4 or 5 TRAEs reported. One patient discontinued cabozantinib due to a TRAE and no patients discontinued belzutifan due to a TRAE. Serious TRAEs occurred in 2 patients. Dose reductions were reported at rates of 20% and 74% for belzutifan and cabozantinib, respectively.

The most common any-grade TRAEs included anemia (71%), diarrhea (71%), fatigue (63%), dysgeusia (46%), nausea (43%), palmar-plantar erythrodysesthesia (37%), hypertension (34%), increased alanine aminotransferase (31%), increased aspartate aminotransferase (29%), decreased appetite (29%), thrombocytopenia (26%), hypophosphatemia (26%), stomatitis (20%), hypothyroidism (20%), and decreased weight (20%).

Grade 3 TRAEs were reported for anemia, fatigue, palmar-plantar erythrodysesthesia, hypertension. One grade 3 TRAE was reported in each of the following: colitis, abdominal abscess, decreased weight, decreased platelet count, hypoxia, and dyspnea.

“Anemia and hypoxia are 2 AEs of clinical or special interest because they are associated with

belzutifan therapy,” Merchan noted. “HIF-2α upregulated erythropoietin expression, and therefore, inhibition of this transcription factor results in reductions in erythropoietin and may result in anemia.”

Of the 25 patients with anemia, 7 patients received erythropoiesis-stimulating agents and 1 patient received a blood transfusion.

“The mechanism of belzutifan hypoxia is not well understood, however, what hypothesis states is that HIF-2α inhibition may impair the pulmonary arterial vasoconstrictive response to ventilation/perfusion mismatch, which may result in hypoxia,” Merchan added. Hypoxia was managed in the 2 individuals, with supplemental oxygen given to 1 patient and dose reduction in the second patient.

“Only 1 patient discontinued treatment, and it was [identified as being related to TRAEs with] cabozantinib, so this seem to be a safe combination, but we still need to be careful with hypoxia in other specific characteristics of belzutifan,” Fay said. 

“Cabozantinib plus belzutifan results in encouraging activity in treatment-naïve clear cell RCC, but longer follow-up is needed for survival outcomes. There is a rationale for higher responses in an angiogenesis-driven population and randomized trials evaluating the combination of belzutifan in different stages of the disease are ongoing.”

The phase 3 LITESPARK-011 trial (NCT04586231) will investigate belzutifan plus lenvatinib in patients with previously treated advanced clear cell RCC and is open for enrollment.

1. Choueiri TK, Bauer T, Merchan J, et al. Phase II study of belzutifan plus cabozantinib as first-line treatment of advanced renal cell carcinoma (RCC): cohort 1 of LITESPARK-003. 

. 2022;33(suppl 7):S660-S680. doi:10.1016/annonc/annonc1072

2. Jonasch E, Donskov F, Iliopoulos O, et al. Phase II study of the oral HIF-2α MK-6482 for Von Hippel-Lindau disease–associated renal cell carcinoma. 

. 2020;38(suppl 15):5003. doi:10.1200/JCO.2020.38.15_suppl.5003

Articles

“Responses occurred across all International mRCC Database Consortium risk groups—both in the favorable and intermediate/poor risk groups,” said Jamie R. Merchan, MD.

Belzutifan/cabozantinib combo shows promise in first-line renal cell carcinoma

Mitomycin gel (Jelmyto) can be safely and effectively administered through antegrade instillation to patients with low-grade upper tract urothelial cancer, according to a retrospective review of real-world data presented at the 2022 AUA Annual Meeting.

Administration of mitomycin gel via retrograde administration using a ureteral catheter is more widely used than antegrade administration via percutaneous nephrostomy tube. For example, all evaluable patients in the pivotal OLYMPUS trial (NCT02793128) received 6 once-weekly treatments via a retrograde approach.

Investigators noted that patients required general anesthesia for the procedure, which may correlate with an increased cost and morbidity. Additionally, repeat procedures via catheter may be a contributing factor to the development of ureteric stenosis.

Mitomycin gel was approved for either antegrade or retrograde administration in 2020 based on data from the phase 3, single-arm OLYMPUS study.

 To circumvent the associated complications with retrograde administration, investigators pooled data from multiple institutions at which patients received mitomycin gel via antegrade administration. All patients underwent induction therapy of 6 once-weekly administrations of mitomycin gel administered using percutaneous nephrostomy tube.

The retrospective analysis identified 26 patients who received treatment across 4 institutions. In terms of efficacy, 50% of patients had a complete response (CR) and 46% had a partial response (PR) at postinduction ureteroscopy, with 1 patient experiencing progression to invasive disease. Further, at a median follow-up of 7 months, no patients with a CR experienced disease recurrence.

In an analysis of the safety data, no patients reported impaired renal function during the follow-up period and 15% of patients reported ureteral stenosis. Other adverse effects included fatigue (27%), flank pain (19%), urinary tract infection (12%), sepsis (8%), and hematuria (8%). No patients died on treatment.

“[Mitomycin gel] is efficacious as a [chemoablation] agent in adult patients with low-grade upper tract urothelial cancer, and while it’s FDA approved for both antegrade and retrograde administration, prior reports are limited to the retrograde experience,” study investigator Kyle Rose, MD, a urologic oncology fellow at Moffitt Cancer Center in Tampa, Florida said in a news release.

 “These data provide additional evidence that instillation via a nephrostomy tube is an effective instillation method with a safety profile that offers an encouraging option to appropriate patients.”

Nine patients (35%) received at least 1 dose of maintenance therapy with mitomycin gel and 6 patients (23%) in the retrospective analysis had solitary kidneys.

“In addition to the lower morbidity profile, percutaneous administration allowed for chemoablation without the use of general anesthesia,” the study authors wrote, noting that larger studies are needed to conclusively identify potential advantages of antegrade vs retrograde approaches.

Mitomycin gel is indicated for the primary chemoablation treatment of patients with low-grade upper tract urothelial cancer. The reverse thermal gel contains 4 mg of mitomycin per mL of gel and is instilled via antegrade or retrograde administration only becoming a semisolid gel at body temperature. The gel dissolves during urine production over 4 to 6 hours, allowing for increased time at the primary tumor site.

In a final analysis of OLYMPUS, among 71 patients in the intention-to-treat population, 59.2% had a CR and 11.3% had a PR. Emergence of high-grade disease was reported among 8.5% of patients and no response was observed in 16.9% of patients. Additionally, investigators noted that 34 patients had tumors which were deemed unresectable at baseline and 58.8% of patients in that group had a CR.

The durability of CR at 12 months was 82% (95% CI, 66%-91%) with 56% (95% CI, 40%-72%) of patients maintaining CR at a 12-month analysis.2 In terms of safety, investigators highlighted ureteric obstruction may increase in tandem with the number of doses and procedures. The most common incidence was documented as ureteric stenosis (43.7%) and was reported after a median of 6 instillations.

Among patients with a CR, 29 went on to receive maintenance therapy for a median of 6 instillations (range, 1-11).

Rose K, Narang G, Rosen G, et al. Antegrade administration of reverse thermal mitomycin gel for primary chemoablation of upper tract urothelial carcinoma via percutaneous nephrostomy tube: a multi-institutional real-world experience. 

Matin SF, Pierorazio PM, Kleinmann N, et al. Durability of response to primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel: OLYMPUS trial final report. 

. 2022;207(4):779-788. doi:10.1097/JU.0000000000002350

FDA approves mitomycin for low-grade upper tract urothelial cancer. FDA. April 15, 2020. Accessed May 16, 2022. bit.ly/3Pp3g5Z

UroGen highlights new data presented at AUA that adds to the evidence supporting in-office nephrostomy tube administration of Jelmyto, the only non-surgical, kidney-sparing treatment for adults with low grade upper tract urothelial cancer. News release. UroGen Pharma Ltd. May 16, 2022. Accessed May 16, 2022. bit.ly/3MBaguV

“[Mitomycin gel] is efficacious as a [chemoablation] agent in adult patients with low-grade upper tract urothelial cancer, and while it’s FDA approved for both antegrade and retrograde administration, prior reports are limited to the retrograde experience,” said study investigator Kyle Rose, MD.

Antegrade instillation of mitomycin gel is effective in patients with UTUC

Clinical outcomes, including delay to recurrence, were not significantly improved for patients with bacillus Calmette-Guérin-unresponsive non–muscle invasive bladder cancer undergoing treatment with a combination of the recombinant pox-viral vector vaccine Panvac and bacillus Calmette-Guérin (BCG).

Results of the phase 2 study (NCT02015104) were presented at the 2021 American Urologic Association Annual Meeting.

Patients with high-grade NMIBC who did not respond to 1 or more induction courses of intravesical BCG were randomized to receive BCG (n = 15) or BCG plus Panvac (n = 15). The 12-month recurrence-free survival (RFS) rate was 42.9% (95% CI, 22.9%-80.0%) for those who received BCG alone compared with 44.4% (95% CI, 24.8%-79.9%) for those who received the combination (

The median time to recurrence was 11.7 months vs 9.9 months, respectively (

 = .77). The RFS rate for entire population was 43.3% (95% CI, 27.9%-66.8%).

The 12-month progression-free survival rates were 79.6% (95% CI, 56.9%-100%) and 78.6% (95% CI, 59.8%-100%) for patients treated with BCG alone and BCG plus Panvac, respectively.

Four patients from the BCG alone arm and 5 patients from the combination arm sought radical cystectomy following treatment.

In terms of baseline histologic characteristics, 14 patients had Ta, 7 had T1, 6 patients had carcinoma in situ alone, 2 had carcinoma in situ with Ta, and 1 had carcinoma in situ with T1. Additionally, 33% of patients (n = 10/30) had at least 2 prior induction courses of BCG.

The vaccine is designed to enhance the presentation of CEA and MUC-1, which are overexpressed in certain cancers, and activate cytotoxic T-lymphocyte response. The therapy consists of a recombinant vaccinia viral vector, a modified vaccinia Ankara-Bavarian Nordic, and a recombinant fowlpox vector. It is administered via a vaccinia priming dose, followed by multiple boosting doses of the fowlpox vector.

Participants enrolled to the phase 2 trial received BCG in 6 weekly injections; those in the Panvac arm received the vaccine in 5 injections over 15 weeks.

In the inclusion criteria for the study, investigators noted that all subclassifications for BCG failure would be considered for inclusion into the study, including BCG-refractory, -resistant, and -relapsing.

Investigators noted in the abstract that the trial was “unique” stating, “It originated prior to the definition of BCG-unresponsive disease and at least a third of the patients on this trial were already BCG unresponsive upon enrollment and received more BCG.”

In a guidance for developing drugs and biologics for treatment, the FDA defined BCG-unresponsive disease as having at least 1 of the following characteristics: persistent or recurrent carcinoma in situ with or without recurrent Ta/T1 disease within 12 months of the completion of adequate BCG therapy, recurrent high-grade Ta/T1 disease within 6 months of the completion of adequate BCG therapy, and/or T1 high-grade disease at the first evaluation after a BCG induction course.

Further, the FDA defined adequate BCG is defined as at least 5 of 6 doses of an induction course plus at least 2 of 3 doses of maintenance therapy, or at least 5 of 6 doses of an induction course plus at least 2 of 6 doses of a second induction course.

“Unlike [ongoing] trials, this trial had a comparison group of BCG alone and, despite the heavy pretreatment in up to a third of patients, the RFS in both arms was still comparable to what has been seen in current BCG unresponsive trials,” the investigators concluded.

The abstract was presented by Ragheed Saoud, MD, a urologist at Northwell Health in Riverside, New York.

1. Saoud R, Telfer S, Marfur M, et al. Clinical outcomes of a randomized, prospective, phase II study to determine the efficacy of bacillus Calmette-Guerin (BCG) given in combination with Panvac versus BCG given alone in adults with high grade BCG-refractory non-muscle invasive bladder cancer. 

. 2021;206(suppl3):e302. doi:10.1097/JU.0000000000002001.14

2. CEA-MUC-1-TRICOM vaccine CV301. National Cancer Institute. Accessed September 13, 2021. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cea-muc-1-tricom-vaccine-cv301

3. Study of bacillus Calmette-Guerin (BCG) combined with Panvac versus BCG alone in adults with high grade non-muscle invasive bladder cancer who failed at least 1 course of BCG. ClinicalTrials.gov. Updated January 22, 2020. Accessed September 13, 2021. https://clinicaltrials.gov/ct2/show/NCT02015104

4. BCG-unresponsive nonmuscle invasive bladder cancer: developing drugs and biologics for treatment guidance for industry. FDA. 2018. Accessed September 13, 2021. https://www.fda.gov/media/101468/download

The 12-month recurrence-free survival rate was 42.9% for those who received BCG alone compared with 44.4% for those who received the combination.

Combination Panvac-BCG does not significantly improve outcomes in non–muscle invasive bladder cancer

Two-year follow-up data for the nadofaragene firadenovec shared during the 2021 American Urologic Association Annual Meeting showed that the novel intravesical gene therapy maintained its efficacy in patients with bacillus Calmette-Guérin (BCG) unresponsive non–muscle invasive bladder cancer (NMIBC).

Long-term findings from 2 cohorts of a phase 3 study (NCT02773849) were shared at the meeting. Investigators reported that among 103 patients with carcinoma in situ (CIS) with or without Ta/T1, 20 patients (19.4%) remained free from high-grade recurrence. Further, of the 55 patients who achieved a complete response (CR) at 3 months following their first dose of nadofaragene firadenovec, 20 (36.4%) remained disease free at 24 months.

In the cohort of patients with high-grade Ta/T1 without CIS (n = 48), 16 patients (33.3%) did experience disease recurrence and 16 (47.5%) of the 35 patients who achieved a complete response at 3 months did not experience high-grade recurrence at 24 months.

As of the September 2020 data cutoff, 62.1% (n = 64/103) of patients with CIS with or without Ta/T1 remained on study. The rate was similar in the high-grade Ta/T1 cohort (68.8%; n = 33/48).

“Nadofaragene [firadenovec] represents a potential novel treatment option for patients with high-grade BCG-unresponsive NMIBC,” said Anne K. Schuckman, MD, in a presentation of the data for the first cohort of patients. She added that the therapy holds the potential to “advance the current treatment paradigm” for these patients. Schuckman is an assistant professor at the Keck School of Medicine at the University of Southern California (USC), and director of urologic oncology at the Los Angeles County + USC Medical Center.

Yair Lotan, MD, who presented the results of the high-grade Ta/T1 cohort, concurred, adding that “[nadofaragene firadenovec] demonstrates sustained durability of response.”

Lotan is a professor of urology and holds the Helen J. and Robert S. Strauss Professorship in Urology at UT Southwestern Medical Center. He is also chief of urologic oncology and the Jane and John Justin Distinguished Chair in Urology as well as the medical director of the urologic clinic at UT Southwestern and Parkland Health and Hospital System.

The multicenter, open-label study enrolled 157 patients with high-grade BCG-unresponsive NMIBC to 2 cohorts: those with CIS with or without Ta/T1 (n = 107) and high-grade Ta/T1 without CIS (n = 50); 103 and 48 patients were included in the efficacy analysis, respectively.

Nadofaragene firadenovec was administered as a single intravesical 75-mL dose of (3 × 1011 viral particles/mL) over 1 hour and was given once every 3 months for up to 4 doses, with additional dosing permitted at investigator’s discretion. The intravesical delivery of the agent prolongs the exposure of the bladder to the human recombinant interferon α-2b (INFα-2b).4 In preclinical studies, IFNα-2b production resulted in tumor regression, presenting a potential avenue for treatment of patients whose tumors do not respond or recur after BCG.

BCG-unresponsive disease was defined as persistent high-grade T1 recurrence occurring within 12 months of BCG initiation, relapse with CIS after initial CR less than or equal to 12 months after last BCG treatment, or relapse with high-grade Ta/T1 NMIBC after last BCG treatment.

Baseline characteristics differed slightly between the 2 cohorts.

Patients in the CIS cohort had a median age of 72 years, 89% of patients were men, and 99% received 2 or more prior courses of BCG prior to enrollment. Specifically, 42% of patients received 2 courses and 57% received 3 or more courses of BCG. In terms of disease stage at study entry, 76% had CIS only, 20% had Ta plus CIS, and 5% had T1 plus CIS. The median time from initial diagnosis of bladder cancer was 20 months.

Those in the Ta/T1 cohort had a median age of 71 years, 68% of individuals were men, and 90% of patients received 2 or more prior BCG courses; 56% received 2 courses and 34% received 3 or more courses. The time from initial diagnosis of bladder cancer was 15 months and 70% of patients had Ta disease and 30% had T1 disease.

At 12 months, protocol mandated a 5-site biopsy, which includes the dome, trigone, right and left lateral walls, and the posterior wall. The primary end point was CR in patients with CIS with or without high-grade Ta/T1 papillary disease.

The trial met its primary end point of CR within 12 months. Specifically, 53.4% (95% CI, 43.3%-63.3%) of patients in the CIS cohort (n = 103) had a CR, all of which occurred at 3 months. The median duration of CR was 9.69 months (95% CI, 9.17-not estimable [NE]); 25 patients (24.3%; 95% CI, 16.4%-33.7%) were free from high-grade recurrence at 12 months.

Twelve-month data for the high-grade Ta/T1 cohort (n = 48) trended slightly higher with 72.9% (95% CI, 58.2%-84.7%) of patients achieving a CR at 3 months and 21 patients (43.8%; 95% CI, 29.5%-58.8%) were recurrence free at 12 months. The median duration of CR was 12.35 months (95% CI, 6.67-NE).

In terms of patients who proceeded to cystectomy at 24 months of the 20 patients in the CIS cohort who had a durable CR at 24 months, 50% went on to cystectomy; for those who did not achieve a CR (n = 48), 23 underwent cystectomy by 24 months. Of the 48 patients who did not achieve a CR, 40 had high-grade recurrence, 7 did not meet the sponsor definition of CR at 3 months, and 1 patient discontinued treatment.

Overall, the cystectomy-free survival rate for this cohort was 64.6% (95% CI, 54.1%-73.3%). Further, the overall survival (OS) rate was 94.4% (95% CI, 87.0%-97.6%).

For the patients in the high-grade Ta/T1 cohort, of those who were high-grade recurrence free at 24 months (n = 16), 7 had cystectomy by 24 months. For those patients who were not high-grade recurrence free at 3 months (n = 13), 4 proceeded to cystectomy by 24 months. The cystectomy-free survival rate was 69.8% (95% CI, 53.4%-80.9%) and the OS rate was 93.2% (95% CI, 80.4%-97.8%).

Finally, in terms of safety, both investigators reported that most drug-related adverse effects (AEs) were transient and localized with a median duration of 2 or fewer days. Additionally, most drug-related AEs were grade 1/2 and no grade 4 or 5 AEs were reported in either cohort.

The most common AEs observed in the CIS cohort were discharge around the catheter (24%), fatigue (23%), bladder spasm (18%), micturition urgency (17%), chills (12%), dysuria (10%), and pyrexia (10%).1 The rates for these AEs in the Ta/T1 cohort were 26%, 12%, 14%, 14%, 10%, 16%, and 10%, respectively.

Two patients in this cohort discontinued because of drug-related AEs in the CIS cohort and 1 patient discontinued treatment in the Ta/T1 cohort.

1. Shuckman AK, Lotan Y, Boorjian SA, Cilwa KE, Dinney CPN. Efficacy of intravesical nadofaragene firadenovec for patients with carcinoma in situ (CIS), BCG-unresponsive non-muscle invasive bladder cancer (NMIBC): longer-term follow-up from the phase III trial. 

. 2021;206(suppl 3):e296. doi:10.1097/JU.0000000000002001.01

2. Lotan Y, Shuckman AK, Boorjian SA, Cilwa KE, Dinney CPN. Phase III trial of intravesical nadofaragene firadenovec in patients with high-grade, BCG-unresponsive, non-muscle invasive bladder cancer: two year follow-up in the Ta/T1 cohort. 

. 2021;206(suppl 3):e296. doi:10.1097/JU.0000000000002001.02

3. Instiladrin in patients with bacillus Calmette-Guerin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC). ClinicalTrials.gov. Updated September 10, 2021. Accessed September 11, 2021. https://clinicaltrials.gov/ct2/show/NCT02773849

4. Boorjian SA, Alemozaffar M, Konety BR, et al. Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial. 

. 2021;22(1):107-117. doi:10.1016/S1470-2045(20)30540-4

5. Shore ND, Boorjian SA, Canter DJ, et al. Intravesical rAd-IFNα/Syn3 for patients with high-grade, bacillus Calmette-Guerin-refractory or relapsed non-muscle-invasive bladder cancer: a phase II randomized study. 

. 2017;35(30):3410-3416. Published cor-rection in 

Long-term findings from 2 cohorts of a phase 3 study showed sustained efficacy with the novel intravesical gene therapy in patients with BCG-unresponsive non–muscle invasive bladder cancer. 

Brittany Lovely

Articles

Belzutifan/cabozantinib combo shows promise in first-line renal cell carcinoma

Antegrade instillation of mitomycin gel is effective in patients with UTUC

Combination Panvac-BCG does not significantly improve outcomes in non–muscle invasive bladder cancer

2-year update shows nadofaragene firadenovec maintained efficacy in NMIBC