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Neoadjuvant cabozantinib was safe and induced a reduction in tumor size in all patients with locally advanced nonmetastatic clear cell renal cell carcinoma enrolled in a phase 2 trial.
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Patients with VHL-mutated ccRCC and VHL–wild type disease often had low positive PD-L1 expression.
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The higher starting dose of lenvatinib was also associated with a prolonged time to deterioration.