Manoj Monga, MD

Robotics has become commonplace in urology, particularly in robot-assisted surgery. It has facilitated the spread of laparoscopy to enable surgeons who were not originally trained in laparoscopic surgery and also improved surgeon ergonomics, if not patient outcomes.

While patients have demonstrated quicker times to return of urinary continence after robot-assisted laparoscopic prostatectomy (RALP), there has been no real difference in long-term survival or positive surgical margin rate. This equivalence is acceptable compared to standard open radical prostatectomy; additionally, robot-assisted laparoscopy may make it easier for the surgeon to operate in the pelvis given that he or she can use three-dimensional vision, magnification, and movement scaling with instruments that have six degrees of freedom compared to only four degrees of freedom in laparoscopic instruments. RALP has become the standard for radical prostatectomy in the United States and many other parts of the world, as rates of open prostatectomy have declined by over 70% in the past few years 

Ureteroscopy has been used commonly for stone removal since the 1990s, particularly with the widespread adoption of the holmium:YAG laser for lithotripsy. Challenges have included transitioning from semi-rigid ureteroscopy to flexible ureteroscopy. Rigid ureteroscopes were initially designed by Dr. Demetrius Bagley and ACMI and had a short learning curve for urologists who were already familiar with rigid cystoscopy.

When flexible ureteroscopes became available, a new skill set for urologists to learn became apparent, particularly for those not familiar with flexible cystoscopy. As a result, flexible ureteroscopy was only adopted by a portion of urologists and sometimes with a wide range of success and differences in complications 

In addition to requiring a new skill set, the cost of flexible ureteroscopy often prohibited its everyday use in certain regions. This financial barrier resulted in an evolution of miniature-sized percutaneous nephrolithotomy (PCNL) instruments: super mini-perc, ultra mini-perc, super ultra-mini perc, etc. Techniques were developed to bypass the need for retrograde flexible ureteroscopy and instead offered percutaneous access using rigid instruments with laser lithotripsy and basketing.

While these mini-perc options offer fewer complications than full-sized PCNL, they are still more invasive than ureteroscopy and carry a higher potential for renal bleeding 

 Flexible ureteroscopy is starting to penetrate these areas, but the skills necessary to make this an effective and reproducible modality must still be learned and mastered. This presents an opportunity where robotic assistance in flexible ureteroscopy could make a big difference by offering the same enabling assistance that robots did for laparoscopic surgery. Robotic ureteroscopy may make novice ureteroscopists excel at flexible ureteroscopy and create opportunities for patients to benefit from minimally invasive approaches to their stone disease.

The Roboflex (ELMED) was one of the first robots used for ureteroscopy and it utilized a robotic control and interface that interfaced and docked with a standard flexible fiberoptic ureteroscope 

 While not having to contort their hands, wrists, or limbs and being able to stand further back from the C-arm radiation source were accompanying advantages of this robot, the surgeon was still limited within the confines of the limitations of the existing ureteroscope movement. Newer robotic endosocopes may have more degrees of freedom, just as robotic instruments developed “wrists,” and may be more akin to an elephant’s proboscis that can twist and reach more places.

New agents may offer hope for two forms of hyperoxaluria

Auris Health, Inc. is pioneering robotic endoscopy in a different way by developing its own endoscope technologies and integrating additional technologies that enhance a surgeon’s capabilities. The company’s Monarch Platform is currently approved for robotic bronchoscopy (figure 1)

 and the instruments and platform could be adjusted for endourology. In fact, the company has signaled interest in endourologic stone management from recent publications

The Auris Monarch Platform for bronchoscopy utilizes an ergonomic and easy-to-understand hand controller similar to those used in modern video games (figure 2)

 By offering additional range of motion at the endoscope tip, controlled through a familiar interface, a robotic ureteroscopy system has the potential to improve the learning curve of the novice flexible ureteroscopist (figures 3 and 4)

Insertion of guidewires and ureteral access sheaths are basic skills that are already within urologists’ skill sets. Once access to the ureter and kidney have been achieved, often the most difficult aspect is controlling a flexible ureteroscope in the kidney, particularly in the lower pole. By having a computer and robot functioning as a follower to the urologist’s commands, it simply becomes a matter of advancing or rotating a controller and deciding where to go.

Several advantages could theoretically be added to such systems. First, ureteroscope manipulation takes time to learn-usually the course of an entire residency-that there is rotation, pitch, yaw, and advance/regress on the ureteroscope handle. To complicate these movements further, there is also the deflection of the tip using the thumb lever. One must learn to simultaneously control several variables in order to arrive at a certain location. With a game controller in hand, the surgeon must simply decide which calyx they want to enter and use the joystick to advance there while the computer calculates the amount of roll, torque, pitch, and yaw in order to get there.

In addition, force sensors could be utilized so that the ureteroscope cannot perforate the renal pelvis, thus increasing safety. If 3-D vision is applied to future ureteroscopy robots, it could also enhance manipulation and visualization. With placement of instruments in the kidney, electromagnetic sensors (EM) could be correlated with the CT preoperatively and therefore a 3-D GPS-like map could be displayed without the use of ionizing radiation, thus minimizing fluoroscopy 

 Nov 14, 2019 [Epub ahead of print]). The surgeon would always be able to know which calyx the endoscope was in by simply looking at a heads-up-display. EM sensing positioning technology has been used in the robotic bronchoscopy system. If real-time ultrasound was added, this could also help guide surgeons to any remaining stones or fragments that have been displaced during the procedure.

A robot-assisted platform could allow the laser fiber or instrument to be fine-tuned with precision using the robot and controller. Ultimately, a robot could theoretically control the ureteroscope and synchronize it with respiration during laser lithotripsy to increase the efficiency of fragmentation. Baskets could be controlled by a robotic system and be used to pull the ureteroscope out of the access sheath, drop the stone, and then return to the exact previous spot since it will remember the location in all vectors.

The obvious safety concern with this use is pulling out a stone that does not fit the sheath and avulsing the ureter. The robot could address this in two ways. First, endoscopic measurement of the stone fragments could be made to ensure that the pieces are small enough to fit through the access sheath. Second, force sensors could be incorporated into the system to prevent ureteral avulsion; it would simply stop retracting and the surgeon would be able to further fragment the stone before extraction.

Laser settings could also be programmed into the robot, and instead of the surgeon stopping to alter the settings, the robot could constantly monitor the types of dust or fragment being produced and the amount of retropulsion or stone movement, then alter the settings as lithotripsy is taking place and the stone is decreasing in mass. Of course, the surgeon would be able to determine at the onset whether the stone should be dusted or fragmented with basket extraction, all while eliminating the need for or reliance on an assistant.

Once synchronization of respiratory movements can be accounted for, this may make lithotripsy very fast and efficient. Ultimately, it is conceivable that the surgeon would place a target on the stone in question, hit a “start” button, and then the robot would control the laser, ureteroscope, fluid irrigation, and laser settings to reduce retropulsion and adjust for respiratory movements to break up the stone into dust. This would all take place while the surgeon stands by at the console.

New robotic technologies will improve the ability of novice ureteroscopists to provide excellent treatment of renal stones and also improve the ability of experts to target stones with better surgeon ergonomics while reducing ionizing radiation from fluoroscopy. The future is bright, and we are at the dawn of the next era of robot-assisted ureteroscopy.

 is associate professor of urologic sciences at the University of British Columbia, Vancouver, and chair of research for the Endourological Society. 

 is associate professor of urology, University of California, San Francisco. 

 is director of the Stevan B. Streem Center for Endourology & Stone Disease at Cleveland Clinic. 

 is professor and chair of urology, Mayo Clinic, Phoenix. 

 Drs. Chew, Chi, Monga, and Humphreys are consultants to Auris Surgical.

 is assistant professor of surgery (urology) at the Center for Reconstructive Urology and Men’s Health, University of Utah, Salt Lake City, and 

is professor of urology, Icahn School of Medicine at Mount Sinai, New York.

Articles

Advances in robotic URS will help target stones and reduce ionizing radiation.

Robotic ureteroscopy: The future of stone management?

	Kidney stone disease is a common and widespread condition with a high prevalence in both males and females. According to a recent cross-sectional analysis of large epidemiologic data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010, the prevalence of the disease has steadily increased over the past few decades. From the same database but for the period between 1976 and 1980, the prevalence rose from 4.9% to 10.6% in men and from 2.8% to 7.1% in women. On average, one in 11 Americans will develop at least one kidney stone in their lifetime 

). Whether this increment represents better and earlier diagnosis of the disease, dietary and lifestyle changes, and/or climate influences remains a matter of discussion.

	Similarly, obesity and weight gain are considered by many a rising epidemic in our society. These conditions seem to have a direct relationship with an entity initially described in the late 1980s as syndrome X and later defined as metabolic syndrome. Metabolic syndrome is known to be a risk factor for multiple systemic and chronic diseases now affecting at least up to 25% of the U.S. population, with comparable numbers in other industrialized nations 

	This article examines the relationship between the metabolic syndrome and kidney stone disease. We explain elements of the metabolic workup and practical strategies for prevention and management of stones in patients with the metabolic syndrome. As will be evident from the article, a multidisciplinary approach incorporating the expertise of a nephrologist, dietitian, and urologist can be of great benefit for these patients.

	The following components are considered for the definition of the metabolic syndrome:

		elevated triglycerides (≥150 mg/dL) or treatment with medication for the condition

		reduced HDL cholesterol (<40 mg/dL in males, <50 mg/dL in females) or treatment with medication for the condition

		elevated blood pressure (systolic ≥130 and/or diastolic ≥85 mm Hg) or treatment for hypertension

		elevated fasting glucose (≥100 mg/dL) or drug treatment for elevated glucose.

	It is now widely accepted that people in whom at least three of these five components are present qualify as having the metabolic syndrome 

). Nephrolithiasis, once thought of as an isolated condition, has gained recognition as a systemic and chronic disease associated with and directly correlated to the metabolic syndrome 

). Higher prevalence rates of uric acid stones in patients with the metabolic syndrome are well documented. These may be caused by increased net acid excretion and impaired buffering caused by defective urinary ammonium excretion thought to be the result of defective insulin signaling and/or possibly fat accumulation in renal cells, a process known as lipotoxicity 

	However, independent of other factors of the metabolic syndrome or diabetes, high total cholesterol and triglycerides have also been associated with an increased risk of uric acid kidney stone formation 

). Despite this, calcium-based kidney stones remain the most common type.

	People with the metabolic syndrome, particularly those with obesity, pose a challenge in management and control of nephrolithiasis recurrence. We recommend a full metabolic workup in patients who have both conditions. Although no randomized controlled trials are available to support this suggestion, it is widely recommended in patients with severe or multiple comorbidities that may predispose for recurrence or complications of the disease 

).  All of these subjects should have baseline kidney function tests, including electrolytes with serum calcium and phosphorus, uric acid, and urine analysis (Metabolic Evaluation: Underuse or Overdone? In: 

Practical Controversies in Medical Management of Stone Disease.

 New York, Springer Science+Business Media, 2014: 1-6). By the same token, 24-hour urine collections should be performed at least once, particularly in morbidly obese patients, 98% of whom have at least one lithogenic risk factor 

). Stone composition analysis should always be done after either a urologic procedure or spontaneous passage.

	Every patient with known urolithiasis should have imaging studies, if not previously performed in an emergency department, to determine stone location and burden. Taking into consideration the abdominal girth and higher incidence of radiolucent stones (by standard KUB) in patients with the metabolic syndrome, as well as the greater difficulty to obtain images by ultrasonography, a lower threshold to obtain CT scans in these patients should be exercised.

	It has been shown that primary prevention in patients at high risk for stone formation is cost effective. General interventions, as in any other patient with kidney stone disease, should be encouraged.

 Such interventions include inexpensive and well-proven treatments as simple as increased water intake to effect up to 2.5 liters of urinary output daily. Although there is much debate about the intake of fluids other than water, it has been demonstrated that higher consumption of sugar-sweetened sodas and punch is associated with an increased risk of kidney stones 

). Restriction of such fluids should be highly encouraged in patients with both conditions, as consumption of beverages with higher contents of sugar and fructose also may worsen visceral obesity, fasting glucose, and triglyceride levels (all part of the metabolic syndrome), and higher refined carbohydrate diets have also been associated with increased urinary calcium excretion.

Similarly, lower ingestion of salt, specifically a sodium target of ≤2,000 mg/day, should also be recommended. This may have a dual effect in the management of elevated blood pressure and decreased levels of hypercalciuria, the latter being the most common abnormal metabolic risk factor encountered in patients with kidney stones. The DASH (Dietary Approaches to Stop Hypertension)-style diet, which is high in fruits and vegetables, moderate in low-fat dairy products, and low in animal protein, has been shown to decrease the risk for kidney stones despite the theoretical increase in foods with higher oxalate content 

). The DASH diet has also been shown to lower blood pressure.

One overlooked aspect of counseling in patients with both conditions is exercise. Although scarce data is available to show the beneficial effects of regular exercise in patients with kidney stones, recent data from a large, prospective, longitudinal multicenter study in postmenopausal women help confirm these beneficial effects. Incident stones were reduced up to 31% in patients undergoing moderate to high physical activity 

). Although these results pertain to postmenopausal women specifically, one could extrapolate the same results to premenopausal women or males. Even if this is not a currently proven fact, the effects in all other aspects of the metabolic syndrome should be good enough to reinforce this intervention to all patients.

	When a metabolic evaluation is performed, it is reasonable to ask whether a patient with metabolic syndrome will comply with dietary recommendations. Our group recently evaluated this question in a study of 214 patients, 29% of whom were obese and 12% of whom were morbidly obese. At a mean follow-up of 10 months, obese stone formers were as successful as those with normal body mass index at improving their diet to optimize their urinary risks (figure), and these changes also led to a decrease in BMI in those who were obese 

	In patients with the metabolic syndrome and recurrent kidney stones, aggressive medical treatment for stone prevention-in addition to the interventions mentioned above-should be instituted. First-line therapy should be a thiazide diuretic with dual intention to treat both elevated blood pressure and hypercalciuria if the latter is present in the 24-hour urine collection. Regardless of this finding, empiric treatment with these medications may still be considered. Special attention should be given to side effects such as hypokalemia, as these patients tend to have elevated aldosterone levels.

	Also, lipid and glucose levels should be followed, as these are common side effects of thiazide diuretics 

). Higher doses of thiazides for prevention of kidney stones may be required than are administered for the treatment of hypertension alone. In patients with known uric acid kidney stones or in those with decreased urinary pH and an unknown type of stone, potassium citrate (Urocit-K) should be used first with a goal to alkalinize the urine to a pH ≥6.5-7.0. Other interventions may be tailored to findings in the metabolic workup such as allopurinol (Zyloprim) for patients with hyperuricosuria or hyperuricemia, even in the absence of gout.

	In patients in whom bariatric surgery is considered for management of morbid obesity and its associated comorbidities, preoperative counseling about the increased risk of calcium oxalate kidney stones is required. In those already known to be stone formers, earlier interventions with goals for higher urinary outputs, higher calcium-containing diets, and lower oxalate consumption should be recommended. This may be difficult in the long term and even more in the immediate postoperative period due to the restrictive effects of the small gastric pouch. Closer vigilance for stone recurrence in these patients should also be exercised and use of supplemental calcium, particularly with meals, should be attempted to decrease absorption of oxalate. The use of oral 

 is on the horizon as a possible alternative for management of this complication.

	Both kidney stones and metabolic syndrome are on the rise. There seems to be a direct correlation between the two entities. Patients with both conditions warrant a more detailed evaluation than the general population, as they also have higher rates of stone recurrence and complicated manifestations. A multidisciplinary approach should be in place for such patients to address not only medications and surgical procedures, but also to emphasize major dietary and lifestyle changes. Such a team approach should include a urologist, nephrologist, and even dietitian for counseling. Medical management should address particular issues, as higher rates of uric acid kidney stones are encountered in this population.

The azoospermic male: Contemporary evaluation and treatment

How to talk to patients about prostate cancer screening

How to manage post-prostatectomy incontinence

 to get monthly news from the leading news source for urologists.
	 

This article examines the relationship between the metabolic syndrome and kidney stone disease. We explain elements of the metabolic workup and practical strategies for prevention and management of stones in patients with the metabolic syndrome.

Manoj Monga, MD

Articles

Robotic ureteroscopy: The future of stone management?

How to prevent stone formation in patients with metabolic syndrome