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Regardless of whether it is given adjuvantly or as salvage therapy, radiation therapy reduces the likelihood of prostate cancer recurrence, according to a study in the International Journal of Radiation Oncology, Biology, Physics (2004; 59: 329-40).

San Francisco--Second-look nephroscopy following percutaneous nephrolithotomy (PNL) could be supplanted by metabolic evaluation and aggressive medical therapy, said researchers from the Duke University Medical Center. Second-look nephroscopy is currently the gold standard for assessing and achieving stone-free status, but the Duke researchers sought to determine whether this additional procedure was necessary.

Studies of the effect of chemotherapy in men with metastatic prostatecancer have been enticing and, at the same time, disappointing. While showingPSA response in some cases, these studies have previously failed to demonstrateimproved survival. This is all about to change, and for the better. We areentering an exciting new era in the management of this patient population.

San Francisco--Continuing a trend of mixed results seen in previousstudies, neoadjuvant chemotherapy with docetaxel (Taxotere) resulted ina significant PSA response but failed to induce any histologic changes inlocally advanced prostate cancer, Cleveland Clinic investigators reportedat the AUA annual meeting.

Oceanside, NY--In men with clinically localized prostate cancer,monotherapy with radical prostatectomy, external beam radiation therapy,or permanent prostate brachytherapy offer the same excellent chance of biochemicalsuccess, according to the results of a large, retrospective study.

San Francisco--Still known primarily for its ability to smoothfacial wrinkles, botulinum toxin A (Botox) is gaining acceptance as a treatmentoption for refractory overactive and neurogenic bladder.

The latest update of AUA guidelines for management of organic erectile dysfunction will focus on novel treatment recommendations and suggestions for study designs that minimize conflicts of interest in post-marketing comparisons of oral drug therapies.

Results from an ex vivo study demonstrating effects of the nonselective alpha-1 receptor antagonist doxazosin (Cardura) on ureteral contractility raises questions about the role of alpha-blocker treatment in the management of ureteral stone disease, say urologists from the University of Wisconsin.

Gynecare, a division of Ethicon, Inc., offers the Gynecare Monitorr urodynamicmeasurement system, featuring a new type of urethral pressure measurementfor stress incontinence-urethral retro-resistance pressure.

Total attendance at this year's AUA annual meeting in San Francisco increasedby about 1,500 over last year's meeting in Chicago, according to unauditedstatistics released on Monday. As of Monday, total professional attendanceat the meeting was 11,538, compared with 10,031 at the 2003 meeting.

American Medical Systems announced Monday that its Apogee System forvaginal vault prolapse repair received FDA clearance. The company said itwill begin physician training in preparation for commercial release laterthis year.

The Coalition for the Advancement of Prosthetic Urology has taken a significantstep in what is likely to be a long march toward securing equitable paymentfor urologic prostheses, said John Mulcahy, MD, chairman of CAPU's boardof directors, during a briefing held during the AUA annual meeting Tuesday.

A large, international, multicenter study has shattered one common assumptionabout renal cell carcinoma. The overall prognosis for chromophobe carcinomasis better than for clear-cell or papillary tumors, rather than the opposite.However, all three tumor types have equivalent survival when adjusted forstage and grade.