Longer-term findings from the phase 2 ARACOG study suggest differences in objectively measured cognitive function between ARPIs.
|Videos|August 5, 2021
Dr. Abida on next steps with PARP inhibitors in prostate cancer
Author(s)Urology Times staff
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Wassim Abida, MD, PhD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses what the next steps should be with PARP inhibitors in prostate cancer. The PARP inhibitors olaparib (Lynparza) and rucaparib (Rubraca) are approved by the FDA for the treatment of patients with metastatic castration-resistant prostate cancer, and other PARP agents are moving through the pipeline.
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Jeffrey M. Spier, MD, discusses how fatigue may impact patient quality-of-life and when dose reduction may be an appropriate treatment strategy.
Jeffrey M. Spier, MD, reviews evidence on ARPI dose reduction in prostate cancer and discusses monitoring treatment response, tolerability, and dose reescalation.
Jeffrey M. Spier, MD, discusses managing ARPI-related fatigue through dose adjustments, patient monitoring, and strategies to maintain treatment adherence.
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VIR-5500 is a PSMA-targeted PRO-XTEN dual-masked T-cell engager entering phase 3 development for prostate cancer.
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