Robert A. Figlin, MD, deputy director, Cedars-Sinai Cancer, discusses results from the phase 2 CANTATA study of cabozantinib (Cabometyx) plus either the novel glutaminase inhibitor telaglenastat (CB-839) or placebo in patients with advanced/metastatic renal cell carcinoma (mRCC) who progressed on immune checkpoint inhibitors or antiangiogenic therapies. Results presented at the 2021 ASCO Annual Meeting showed that the addition of telaglenastat did not improve the efficacy of cabozantinib in mRCC. In the video, Figlin explains key lessons learned from the results.
KIM-1 emerges as biomarker for MRD, atezolizumab benefit in renal cell carcinoma
June 3rd 2024Circulating kidney injury molecule-1 (KIM-1) may be a biomarker for minimal residual disease, disease recurrence, and benefit from adjuvant atezolizumab in patients with renal cell carcinoma at increased risk of recurrence, according to a retrospective analysis of the phase 3 IMmotion010 trial.