In an interview during the 2021 ASCO Annual Meeting Robert J. Motzer, MD, discussed where the combination of pembrolizumab (Keytruda) and lenvatinib (Lenvima) fits into the treatment paradigm for advanced renal cell carcinoma (RCC), based on findings from the phase 3 CLEAR trial. In the study the combination reduced the risk of death by 34% versus sunitinib (Sutent) in the frontline RCC setting. Motzer is the Kidney Cancer Section Head, Genitourinary Oncology Service; and Jack and Dorothy Byrne Chair in Clinical Oncology at Memorial Sloan Kettering Cancer Center.
KIM-1 emerges as biomarker for MRD, atezolizumab benefit in renal cell carcinoma
June 3rd 2024Circulating kidney injury molecule-1 (KIM-1) may be a biomarker for minimal residual disease, disease recurrence, and benefit from adjuvant atezolizumab in patients with renal cell carcinoma at increased risk of recurrence, according to a retrospective analysis of the phase 3 IMmotion010 trial.