A 75-Year-Old Woman with High-Risk Muscle Invasive Bladder Cancer - Episode 4
A bladder cancer expert several ongoing clinical trials in the neoadjuvant and adjuvant setting.
Karim Chamie, MD: Patients with muscle-invasive bladder cancer have access to numerous clinical trials. As we progress into earlier stages of disease, some of the drugs that have been used for patients with muscle-invasive metastatic 2nd-line, 3rd-line settings are now being advanced into the neoadjuvant setting. We have the KEYNOTE-866 study, which is pembrolizumab plus chemotherapy. We have the KEYNOTE-B15 study, which is pembrolizumab plus enfortumab vedotin. We have clinical trials of chemotherapy plus nivolumab, plus or minus IDO inhibitors. We have nivolumab plus NKTR-214, which is a pegylated IL2 agent. We have chemotherapy plus nivolumab, plus or minus IDO inhibitors. We have nivolumab plus ipilimumab. We have additional drugs that were tested in 2nd and 3rd-line settings that are being moved up to the neoadjuvant study. This is a really exciting period for physicians who treat patients with bladder cancer and patients who have recently been diagnosed with bladder cancer as far as the options they have now compared to what they had 5, 10 years ago.
Now, as far as adjuvant treatments, there are also some exciting studies. The IMvigor011 study is adjuvant atezolizumab in those that have circulating tumor DNA. As you recall, the IMvigor010 was negative based on an intent to treat. However, when they actually did a subset analysis of patients who has circulating tumor DNA positivity, those patients benefited significantly as far as recurrence-free survival. I expect to have data being presented in the next couple years where we're probably going to see similar benefits in patients who are getting atezolizumab in the adjuvant setting amongst those that have circulating tumor DNA positivity.
Transcript edited for clarity.
Case: A 75-Year-Old Woman with High-Risk Muscle Invasive Bladder Cancer
Clinical workup and imaging