Opinion|Videos|February 5, 2025
Treatment and Co-Management of mCRPC Patients with Aggressive Disease
Author(s)Jose De La Cerda III, MD, MPH
This video segment explores treatment approaches for PSMA-positive mCRPC patients, algorithms for monitoring liver dysfunction in advanced CRPC, and exciting advancements in mCRPC treatment.
Advertisement
Episodes in this series
Video content above is prompted by the following:
- If the patient is positive for prostate-specific membrane antigen (PSMA), how would you treat the patient?
- What is your algorithm for monitoring patients with liver dysfunction and advanced CRPC?
- What advances in treatment of mCRPC are you most excited about?
Advertisement
Related to this article
Interim phase 3 data show a 58% reduction in the risk of metastasis or death with the addition of darolutamide to ADT + radiation.
Carlos A. Vargas, MD, discusses updated survival outcomes, safety, and the mechanism of SYNC-T SV-102, an investigational in situ immunotherapy for metastatic prostate cancer.
Perioperative durvalumab (Imfinzi) plus neoadjuvant enfortumab vedotin-ejfv (Padcev) cut the risk of EFS events by 49% and death by 42% in cisplatin-ineligible MIBC.
The PROTEUS substudy addresses a key limitation of the main study, which had no surgery-alone control arm.
At a median follow-up of 60.9 months, median EFS was 74.1 months in the pembrolizumab arm and not reached in the placebo arm.
The phase 1/2 CELC-G-201 study found preliminary antitumor activity and manageable toxicity with gedatolisib plus darolutamide in metastatic castration-resistant prostate cancer.
Kim Chi, MD, FRCPC, discusses the rationale and design of the phase 3 KLK2-comPAS trial evaluating pasritamig alone and in combination with JNJ-9401 in patients with mCRPC.
Longer-term findings from the phase 2 ARACOG study suggest differences in objectively measured cognitive function between ARPIs.
Advertisement
Advertisement
Trending on Urology Times
1
Adding darolutamide to ADT and radiation improves MFS in very high-risk localized prostate cancer
2
VOLGA: Durvalumab plus enfortumab vedotin improves EFS, OS in MIBC
3
PROTEUS Substudy: Perioperative apalutamide plus ADT improves EFS vs surgery alone
4
In situ immunotherapy shows encouraging survival findings in prostate cancer
5