
Opinion|Videos|November 12, 2024
Unmet Needs and Clinical Challenges for PSMA Imaging
Author(s)Oliver Sartor, MD
Key Takeaways
- Standardized imaging protocols and interpretation criteria are essential for consistent PSMA imaging results across clinical settings.
- Robust data on the impact of PSMA imaging on patient outcomes is needed to guide treatment decisions effectively.
Oliver Sartor, MD, discusses how unmet needs and clinical challenges for PSMA imaging in prostate cancer patients include standardizing interpretation criteria, addressing false negatives in certain tumor phenotypes, improving accessibility and cost-effectiveness, and developing strategies for patients with low PSMA expression or PSMA-negative disease.
Advertisement
Video content above is prompted by the following:
- What are some unmet needs and clinical challenges for PSMA imaging in patients with prostate cancer?
Advertisement
Related to this article

Exploratory analyses suggest persistent immune remodeling after aglatimagene plus radiation in localized prostate cancer.

Brian Mazzarella, MD, discusses the landscape for intermediate-risk prostate cancer and early VAPOR 2 findings on water vapor ablation.

The phase 3 BiPASS trial is evaluating the use of 68Ga-PSMA-PET in combination with MRI for pre-biopsy prostate cancer detection.

In RTOG 3506, adding enzalutamide to standard ADT and salvage radiotherapy was associated with 2-year PFS benefit.

In the phase 3 PACE-A trial, SBRT and prostatectomy showed similar 8-year disease control in localized prostate cancer, with lower rates of urinary incontinence after SBRT.

Using PSMA-PET imaging and genomic testing to obtain better information earlier in the disease course changes what clinicians can do with diagnosis and treatment planning.

The registrational study is designed to evaluate the diagnostic performance of 68Ga-DOTA-RM2 vs histopathology in prostate cancer.
Advertisement
Advertisement
Trending on Urology Times
1
FDA updates in urology: September 2026
2
John Sfakianos, MD, on integrating ctDNA into bladder cancer trials
3
SBRT, prostatectomy show comparable long-term disease control in PACE-A trial
4
Behind the FDA approval of belzutifan plus lenvatinib in advanced ccRCC, with Robert Motzer, MD
5
