Female Urology

San Diego-Treatment with nitrofurantoin is superior to an estriol-containing vaginal pessary for prevention of urinary tract infections in postmenopausal women, according to results of an Israeli study.

Philadelphia-The City of Brotherly Love has what many say is theleast friendly climate for physicians when it comes to medical liabilityinsurance. Insurance and reimbursement problems, however, are statewidephenomena in Pennsylvania. In Scranton, located in the northeastern cornerof the state, a seven-urologist group has said it will decide in Januarywhether to close.

Bethesda, MD-A screening technique based on the interplay of blood proteinsmay help clearly differentiate between prostate cancer and benign conditionslike BPH, according to a National Cancer Institute study. The test, whichis still under investigation, showed a specificity of 71% in men with marginallyelevated PSA levels, NCI researchers reported.

New minimally invasive techniques for the surgical treatment of stressincontinence have been based on novel concepts concerning the surgical supportof the mid-urethra and the utilization of artificial graft materials. Inthis exclusive Urology Times interview, David Staskin, MD, discusses theevolution of sling techniques and the pros and cons of using artificialmaterials. Dr. Staskin is director of the Section of Voiding Dysfunction,New York Presbyterian Hospital, and associate professor of urology and obstetricsand gynecology, Weill Medical College, Cornell University. The interviewwas conducted by UT Editorial Consultant Philip M. Hanno, MD, of the departmentof urology, University of Pennsylvania, Philadelphia.

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Q What is the current state of prostate cancer markers?With prostate cancer, we are fortunate in that it has the very best markeror combination of markers for any cancer that I'm aware of, short of skincancer where visual markers are quite good. PSA's performance for predictinglocalized prostate cancer probably exceeds the performance of other cancermarkers, such as CA125 for ovarian cancer, CEA for colon cancer, and someof the genetic markers for breast cancer.

Orlando, FL-Currently established T- and Z- bone mineral density scores may require revision in order to accurately assess changes in men receiving androgen deprivation therapy, suggests an Austrian study presented at the AUA annual meeting.

Orlando, FL-The 5-alpha-reductase inhibitor finasteride (Proscar)is associated with symptom improvement in men with category IIIA chronicpelvic pain syndrome, say leading prostatitis researchers.

Orlando, FL-Treatment with an alpha blocker used commonly in men withBPH is associated with improvement of symptoms in men with moderate to severechronic non-bacterial prostatitis, said Perinchery Narayan, MD.

Newton, MA-Matritech Inc. has received FDA clearance to market the NMP22 BladderChek bladder cancer test for use in conjunction with cystoscopy. The test works like a home pregnancy test and returns results while the patient is in the physician's office, the company says.

Presented by Richard A. Santucci, MD, Wayne State University School of Medicine, Detroit.

Presented by Deborah R. Erickson, MD, Pennsylvania State UniversityCollege of Medicine, Hershey.

Presented by Edward Kim, MD, University of Tennessee School ofMedicine, Knoxville.

Presented by John N. Krieger, MD, University of Washington School ofMedicine, Seattle.

Presented by Ricardo Gonzalez, MD, University of Miami Schoolof Medicine.

Presented by John Trachtenberg, MD, University of Toronto.

The incidence of hydronephrosis diagnosed in the neonatal period has increased dramatically with the routine use of ultrasound in obstetrical care. Prior to the mid-1980s, most children with obstructive uropathy secondary to ureteropelvic junction obstruction or ureterovesical junction obstruction were diagnosed after urinary tract infections had occurred or an abdominal mass was noted.

Orlando, FL-A new analysis of data from the National Cancer Institute'snationwide Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screeningtrial suggests that annual PSA screening may not be necessary for many men.

San Francisco-Prostate cancer bone metastases appear to react favorablyto treatment with a new bisphosphonate and the tyrosine-kinase inhibitorsPKI-166 and STI-571, according to studies presented at the American Associationfor Cancer Research annual meeting here.

Characterized by symptoms of urinary frequency, urgency, and urge urinary incontinence, overactive bladder (OAB) is a condition that results from a deficiency in the bladder's ability to store urine and in the onset of involuntary bladder muscle contractions that promote urgency and possibly urine loss.

Group presses for $420 million at NIH and $100 million at Defense Departmentin 2003Washington - The case for bolstering funding for prostate cancerresearch is being pressed on Capitol Hill by a 6-year-old coalition of organizationsand individuals who are determined to end the disease that has accountedfor 15% of all male cancer deaths over the last decade.

New Products as presented in the April 1, 2002 issue of Urology Times

San Francisco - Researchers have successfully induced hypospadias in mice, an accomplishment that observers say provides more compelling evidence in support of the endocrine disruptor hypothesis as an explanation for the increase in hypospadias observed over the past 30 years.

San Francisco-Factors that may help to predict future infertilityin cryptorchid boys-enabling clinicians to intervene earlier-have emergedfrom two long-term studies of cryptorchidism and fertility presented atthe American Academy of Pediatrics Section on Urology annual meeting.

Varicocele was first recognized by Lawrence Dubin, MD, and Richard D.Amelar, MD, as the male reproductive anatomic anomaly most amenable to surgicalcorrection. Varicocelectomy has long since played an important role in theurologist's toolbox. Yet with the emergence of intracytoplasmic sperm injection, a variantof in vitro fertilization in which a single sperm is injected into an ovum,some have questioned the utility of all forms of reproductive therapy otherthan assisted reproductive technologies (ARTs). Among many papers presentedat the American Society for Reproductive Medicine annual meeting-and reportedin this issue of Urology Times-several supported the continued role forvaricocelectomy.