Prostate cancers that are resistant to androgen deprivation therapy are more invasive and are more likely to spread to other organs than are androgen-dependent prostate cancers, according to UCLA researchers. The findings could change the way some prostate cancers are treated, spurring earlier use of hormone therapy to prevent the cancer’s spread, said senior author Robert Reiter, MD.
A single PSA test taken before the age 50 years can be used to predict advanced prostate cancer in men up to 25 years in advance of a diagnosis, according to a study by researchers at Memorial Sloan-Kettering Cancer Center in New York and Lund University in Sweden. The findings, published in the online journal BMC Medicine, should help physicians identify men who would benefit from intensive prostate cancer screenings over their lifetime.
An independent panel convened by the National Institutes of Health found that fewer than half of those experiencing urinary or fecal incontinence report their symptoms to health care providers without prompting, impairing their quality of life and hindering development of prevention and treatment strategies.
A diet low in fat and red meat but high in vegetables and lean protein may significantly decrease the risk of symptomatic BPH, according to researchers at the Fred Hutchinson Cancer Research Center in Seattle.
The American College of Preventive Medicine has found there is insufficient evidence to recommend for or against routine population prostate cancer screening with digital rectal examination or PSA. The college has issued a practice policy statement advising clinicians caring for men, particularly African-American men and those with a family history of prostate cancer, to provide them with information about the potential benefits and harms of screening and the limits of current evidence to allow these patients to make an informed decision about screening (Am J Prev Med 2008; 34:164-70).
Two novel, investigational forms of immunotherapy showed positive outcomes in separate studies reported at the recent Genitourinary Cancers Symposium in San Francisco.
Inderbir Gill, MD, has been appointed chairman of the department of urology at the Cleveland Clinic. The department of urology is one of three departments within the new Glickman Urological and Kidney Institute, along with the department of regional urology and the department of nephrology and hypertension.
Two newer drugs used for the treatment of advanced renal cell carcinoma may be associated with an elevated risk of hypertension and other cardiovascular side effects, according to results of two separate studies.
Researchers at the University of Southern California, Los Angeles, have developed a prostate cancer vaccine that prevented the development of cancer in 90% of young mice genetically predestined to develop the disease, and suggest the same strategy might work for men with rising levels of PSA (Cancer Res 2008; 68:861-9).
Men with prostate cancer who undergo prostatectomy cite sexual dysfunction as the most common side effect after surgery, but urinary dysfunction troubles these patients most, a study from the University of Florida College of Nursing, Gainesville, has found. What’s more, many are not emotionally prepared to face these complications, according to the study, reported in Urologic Nursing (2007; 27:527-33).
Hormonal components in over-the-counter dietary supplements may promote the progression of prostate cancer and decrease the effectiveness of anti-cancer drugs, report researchers at the University of Texas Southwestern Medical Center, Dallas. The findings, which appear in Clinical Cancer Research (2008; 14:607-11), reaffirm that patients should inform their doctors about any herbal or hormonal dietary supplements they are taking or are considering taking.
Assessing the comparative effectiveness and harms of various treatments for localized prostate cancer treatments is difficult because of limitations in evidence, according to a study to be published in the March 18, 2008, edition of the Annals of Internal Medicine.
Researchers analyzing prostate tumors have identified differences in gene expression between African-American and Caucasian men that show the existence of distinct tumor microenvironments in these two patient groups. The study, conducted by investigators at the National Cancer Institute, Bethesda, MD, appears in Cancer Research (2008; 68:927-36).
Sex hormones circulating in the blood do not appear to be associated with prostate cancer risk, according to a study published in the Journal of the National Cancer Institute (2008; 100:170-83).
Urologists and other physicians who treat Medicare patients have been given a short reprieve from the across-the-board 10.1% reimbursement cut that was scheduled for Jan. 1, and have even received a little bit of a raise.
Cherry Hill, NJ-Vision USA's sport bifocal safety glasses have soft rubber nose and ear pads and vents between lenses and frame for enhanced comfort.
In late December, Congress changed the rules, albeit slightly. These changes, among others in 2008, warrant urologists' attention.
Patients undergoing surgical treatment for stress incontinence with concomitant surgical repair, including anterior or posterior/apical repair and other non-prolapse procedures, appear to be at higher risk for wound-related or genitourinary complications.
A study supported the argument that the perineal approach and employment of the gracilis muscle should be the preferred approach for recto-urethral fistula repair.
Concern in the orthopedic community notwithstanding, placement of a suprapubic catheter does not appear to increase the risk of infection in patients with pelvic fracture urethral distraction defect.
Urethroplasty using a tissue-engineered urethral acellular matrix graft is a promising option for reconstruction of severe urethral stenosis.
Urethroplasty using a tissue-engineered urethral acellular matrix graft is a promising option for reconstruction of severe urethral stenosis.
A dorsal onlay, split-thickness extragenital skin graft appears to be a viable alternative for the treatment of long recurring anterior urethral strictures.
Buccal mucosa grafts and penile skin flaps have proven over the last 2 decades to be reliable tissue transfer techniques for reconstruction of intermediate and long urethral strictures.
Offering a concomitant Burch colposuspension to stress-continent women undergoing sacrocolpopexy not only appears to protect patients from later stress urinary incontinence, but it also may improve symptoms of urge incontinence above and beyond the effects of the prolapse repair alone.
Among the many recommendations within the new AUA guideline for the management of nonmuscle-invasive bladder cancer, arguably one of the most important is the idea of repeating resection for patients with high-grade Ta or T1 disease within a few weeks of the initial resection before making a treatment recommendation.
Among the many recommendations within the new AUA guideline for the management of nonmuscle-invasive bladder cancer, arguably one of the most important is the idea of repeating resection for patients with high-grade Ta or T1 disease within a few weeks of the initial resection before making a treatment recommendation.
Women with greater baseline urge incontinence symptoms, those with more advanced pelvic organ prolapse, and postmenopausal women not on hormone replacement therapy (HRT) are all at greater risk for treatment failure when undergoing Burch and sling procedures for stress urinary incontinence.