Lower DNA damage seen with testicular spermatozoa

Apr 01, 2011

A multicenter study comparing aneuploidy rates between concurrent ejaculated and testicular spermatozoa from the same individual reveals lower DNA damage but higher aneuploidy rates among testicular spermatozoa of men with persistently high sperm DNA damage.

Denver-A multicenter study comparing aneuploidy rates between concurrent ejaculated and testicular spermatozoa from the same individual reveals lower DNA damage but higher aneuploidy rates among testicular spermatozoa of men with persistently high sperm DNA damage.

"Embryonic aneuploidy is commonly associated with embryonic anomalies and pregnancy loss," Dr. Moskovtsev explained at the 2010 American Society for Reproductive Medicine annual meeting in Denver.

Previous studies have suggested that testicular spermatozoa of men with severe infertility due to high sperm DNA damage have higher aneuploidy rates than do fertile controls. However, said Dr. Moskovtsev, "To our knowledge, there was no study comparing aneuploidy rates which were obtained the same day from ejaculates and testicular samples from the same individual."