Preoperative PSA remains an accurate measure of cancer recurrence, according to a study from Columbia University Medical Center and New York-Presbyterian Hospital, whose authors say it refutes claims to the contrary.
Preoperative PSA remains an accurate measure of cancer recurrence, according to a study from Columbia University Medical Center and New York-Presbyterian Hospital. The study's authors say it refutes claims to the contrary.
Investigators followed 1,246 prostate cancer patients who underwent radical retropubic prostatectomy with no adjuvant therapy between 1988 and 2003. When controlling for cancer stage and grade (Gleason sum and pathologic stage), preoperative PSA was an accurate predictor of biochemical failure, regardless of when the operation was performed.
Using a concordance index, the accuracy of PSA in predicting outcome, stratified by time period in which the procedure was performed, was statistically equivalent: .65 for the period 1988 to 1993, .66 for the period 1994 to 1998, and .64 for the period 1999 to 2003, researchers reported at the AUA annual meeting.
"Contrary to other recent interpretations, our analysis finds that PSA remains a vital tool for determining risk of recurrence in prostate cancer patients indeed, the predictive ability of the PSA test does not significantly vary over the last 15 years," said Mitchell C. Benson, MD, of New York-Presbyterian/Columbia.
From evidence to practice: Dr. Makarov discusses implementation science in urology
July 25th 2024“What our major contribution is, I think as urologists doing implementation science, is determining the important questions, which we are particularly well-suited to do because we're taking care of the patients,” says Danil V. Makarov, MD, MHS.