Benign Conditions

"Results from these trials show that giving physicians an alert informing them of their patient’s actual risk for antibiotic resistance can help them choose the best antibiotic and reduce extended-spectrum antibiotic use,” says Shruti Gohil, MD, MPH.

The approval is based on 3 clinical trials evaluating the efficacy of different pivmecillinam dosing regimens in comparison with either placebo, another oral antibacterial drug, or ibuprofen.

"I think the main question is just how to disseminate this information. Obviously, there's a huge need," says Megan S. Bradley, MD.

"We found that only about 8% of people in this national survey of over 500 participants had heard of asymptomatic bacteriuria," says Megan S. Bradley, MD.

"Overall, this vaccine is safe in the long term and our participants reported having fewer UTIs that were less severe," says Bob Yang, MBBS, FRCS.

"I think it's about engaging with primary care. Primary care physicians need us to provide them with good education and good back-up," says Caroline Dowling, MBBS, MS, FRACS (Urol).

"I am still struggling with disposing the scopes after each use, both from the environmental aspect and the fact that the scope technically can be used more than once," writes Gopal H. Badlani, MD.

"We definitely need women to be able to access care quickly and efficiently. But, putting antibiotics at the forefront is not going to be the answer," says Caroline Dowling, MBBS, MS, FRACS (Urol).

"Talking about the variety that's out there, the lack of regulation, and having things that are independently verified by labs can also enhance the patient outcome," says Bilal Chughtai, MD.

The study is assessing RECCE 327 across the infusion times of 15, 20, 30, 45, and 60 minutes at the dose level of 3000 mg.

“But all in all, one thing we did see was that [with] the data for saw palmetto, there was a signal that does seem promising, especially when used in combination with other agents,” says Bilal Chughtai, MD.

Postoperative urinary retention is a common outcome after surgical procedures for pelvic organ prolapse and stress urinary incontinence.

"We have over 30 years of safety data, and no adverse events in over 30 years," says Heather Florio.

Liposomal tacrolimus led to improvements in hematuria, bleeding sites on cystoscopy, microscopic urine analysis for red blood cells, and urinary symptoms.

Questions spanned urologic conditions such as benign prostatic hyperplasia, overactive bladder, erectile dysfunction, kidney stones, Peyronie disease, and recurrent urinary tract infections.

“Men with and without retention all do very well from the voiding standpoint with relatively low rates of complications,” says Claire S. Burton, MD.

"Right now, the longest-term studies are the WATER trials, which have published 5-year outcomes. But we know that a subset of men will require retreatment over time," says Claire S. Burton, MD.

"What we found is that those with acute urinary retention took longer to ultimately pass their trial without a catheter, meaning that they were voiding without the use of any catheterization," says Claire S. Burton, MD.

The multiplex polymerase chain reaction/pooled antibiotic susceptibility test was associated with a 44.4% lower mean total UTI-related cost compared to standard urine culture.

“I would say that these conditions are highly heterogeneous, and we've identified a number of factors that relate to different ways that the disease progresses and different ways that patients feel about the progression of their disease,” says Alisa J. Stephens-Shields, PhD.

The findings suggest creatinine-based eGFR equations alone may be inaccurate, and cystatin C or combined eGFR equations may be a more accurate assessment of kidney function in this population.

Cleveland Clinic surgeons describe a new technique for harvesting a rectal mucosa graft.

“We would like to use all of what we've learned in the MAPP to move back into the space of clinical trials and trying to identify effective therapies for this condition,” says Alisa J. Stephen-Shields, PhD.

“We were a bit surprised that the males with IC/BPS didn't look more like the females with regard to the magnitude of decrease in urinary symptom severity required to feel better,” says Alisa J. Stephens-Shields, PhD.

“As part of the [MAPP] network, and the research that it did, we recognized that it was really important to consider pelvic pain symptoms separately from urinary symptoms,” says Alisa J. Stephens-Shields, PhD.

"It may be something that practicing urologists could already start speaking to their patients about," says Siobhan Sutcliffe, PhD, ScM, MHS.

"We used data from this study to see whether having a greater number of flares independently impacted patients’ quality of life as well as their healthcare seeking activity," said Siobhan Sutcliffe, PhD, ScM, MHS.

The study authors maintain there is no current evidence in the literature indicating that CT use is superior to other imaging modalities in reducing morbidity or improving outcomes in patients with urinary stone disease.

The researchers assessed gender differences in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).

“We observed profound differences in the detection work up and management of chronic kidney disease suggesting suboptimal care among women,” said Juan Jesus Carrero, PharmD, PhD.