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In a study identifying the risk of major birth defects associated with different types of assisted reproductive technology, Australian researchers have reported a significantly higher risk of birth defects involving intracytoplasmic sperm injection (ICSI) compared to in vitro fertilization (IVF).

About one-third of computed tomography scans performed following an inconclusive abdominal ultrasound examination have positive findings, according to a recent study. Follow-up scans appear to be most useful in the diagnosis of renal lesions.

This list of U.S.-based National Institutes of Health trials is derived from the NIH's database and includes phase I-III overactive bladder trials and phase IV BPH trials that are currently recruiting participants. This list is current as of April 19, 2012. For more information, view the complete database at http://ClinicalTrials.gov.

Signs of the sea change to come in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) will be part of the 2012 AUA annual meeting. Next year should bring even more, as the National Institute of Diabetes and Digestive and Kidney Diseases and pharma research get readied for meeting debuts.

The FDA recently issued a complete response letter for Amgen Inc.'s supplemental Biologics License Application for the RANK ligand inhibitor denosumab (XGEVA) to treat men with castration-resistant prostate cancer at high risk of developing bone metastases.