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A small percentage of males born with cryptorchidism are more likely to have genetic mutations, including those for a syndrome that is a common genetic cause of infertility, according to a study by Italian researchers.

A new report from the nation's leading cancer organizations shows that, for the first time since the report was first issued in 1998, both incidence and death rates for all cancers combined are decreasing for both men and women, driven largely by declines in prostate, breast, and other common cancers.

Selenium may aid in the prevention of high-risk bladder cancer, according to a study by researchers from Dartmouth Medical School, Lebanon, NH. The news follows a less-encouraging report from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showing that supplementation with selenium or vitamin E was not associated with a lower risk of prostate cancer.

The FDA has accepted the new drug application for a 6-month formulation of triptorelin pamoate (Trelstar), a luteinizing hormone releasing hormone agonist for the palliative treatment of advanced prostate cancer, according to Watson Pharmaceuticals, the drug's manufacturer.

A European phase III double-blind placebo controlled study of PSD502, a proprietary formulation of lidocaine and prilocaine for the treatment of premature ejaculation, has met its three co-primary endpoints of intra-vaginal ejaculation latency time (IELT) and index of premature ejaculation (IPE), Plethora Solutions Holdings PLC has announced.

Absorption of oxybutynin chloride topical gel, an investigational therapy for overactive bladder, is not affected by showering or sunscreen use, according to data presented at the Society of Urologic Nurses and Associates annual conference in Philadelphia.

Evidence of a relationship between prostate inflammation and lower urinary tract symptoms exists in men enrolled in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, a 4-year, phase III, placebo-controlled study that evaluates whether dutasteride (Avodart) decreases the risk of biopsy-detectable prostate cancer.

A novel androgen receptor antagonist known as MDV3100 appears to show durable anti-tumor activity in castration-resistant prostate cancer patients as measured by PSA declines, radiographic findings, circulating tumor cell changes, and time on treatment, according to an ongoing phase I-II trial.

Kidney stones may damage the kidneys and lead to chronic kidney disease, according to researchers from the Mayo Clinic, Rochester, MN. In extreme cases, individuals with chronic kidney disease caused by kidney stones may even need dialysis or kidney transplants.

Statin drugs, used for the treatment of elevated cholesterol, appear to lower PSA values, according to researchers at the Duke University Prostate Center and the Durham, NC, Veterans Affairs Medical Center. But whether the drugs prevent prostate cancer growth or just mask it is still unknown.